Molecular evolution of stress-response gene Leptin in high-altitude Chinese snub-nosed monkeys (Rhinopithecus genus)
文献类型：期刊论文
| 作者 | Wang XP1,2; Jin W1,2; Yu L[*]1,2; Zhang YP[*]1,2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2010 |
| 卷号 | 55期号:36页码:4132-4135 |
| 关键词 | Leptin Chinese snub-nosed monkeys high-altitude adaptation |
| 通讯作者 | yuli1220@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Chinese snub-nosed monkeys (genus Rhinopithecus, subfamily Colobinae), including R. bieti, R. brelichi and R. roxellana, are well-known as the non-human primates with the highest known altitudinal distribution. They represent an interesting model organism of adaptation to the extreme environmental stresses. However, no study at the molecular level has yet been reported for the high-altitude adaptation in Chinese snub-nosed monkeys. Leptin, as an adipocyte-derived hormone, is believed to play an important role in energy homeostasis in adaptation to high altitude environments. In the present study, we sequenced and compared leptin sequences of the Chinese snub-nosed monkeys (R. bieti and R. roxellana) with their lowland close relative R. avunculus and other Colobines. Unexpectedly, no amino acid changes were observed in the 7 Colobinae species examined, including the 2 Chinese snub-nosed monkeys, indicating no difference in the evolutionary pattern of the Leptin gene between high-altitude monkeys and their lowland counterparts. In contrast to a previous finding of adaptive evolution of Leptin gene in plateau pikas, our study suggests that this gene may not have an important role in high-altitude adaptation of Chinese snub-nosed monkeys. Other nuclear genes associated with energy metabolism, or mitochondrial genes, are most likely to be involved the molecular mechanism underlying adaptation of these monkeys to cold and hypoxia associated with the highland environment. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (2007CB411600) and National Natural Science Foundation of China (U0836603). |
| 语种 | 英语 |
| 公开日期 | 2011-01-29 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6560]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Wang XP,Jin W,Yu L[*],et al. Molecular evolution of stress-response gene Leptin in high-altitude Chinese snub-nosed monkeys (Rhinopithecus genus)[J]. CHINESE SCIENCE BULLETIN,2010,55(36):4132-4135. |
| APA | Wang XP,Jin W,Yu L[*],&Zhang YP[*].(2010).Molecular evolution of stress-response gene Leptin in high-altitude Chinese snub-nosed monkeys (Rhinopithecus genus).CHINESE SCIENCE BULLETIN,55(36),4132-4135. |
| MLA | Wang XP,et al."Molecular evolution of stress-response gene Leptin in high-altitude Chinese snub-nosed monkeys (Rhinopithecus genus)".CHINESE SCIENCE BULLETIN 55.36(2010):4132-4135. |
入库方式： OAI收割
来源：昆明动物研究所
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