Gene duplication plays a major role in gene co-option: Studies into the evolution of the motilin/ghrelin family and their receptors
文献类型：期刊论文
| 作者 | He J1; David IM1,2; Zhang YP[*]1,3 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2011 |
| 卷号 | 56期号:25页码:2690-2697 |
| 关键词 | ghrelin ligand motilin receptor gene family coevolution gene interaction |
| 通讯作者 | zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Extant genes can be modified, or 'tinkered with', to provide new roles or new characteristics of these genes. At the genetic level, this often involves gene duplication and specialization of the resulting genes into particular functions. We investigate how ligand-receptor partnerships evolve after gene duplication. While significant work has been conducted in this area, the examination of additional models should help us better understand the proposed models and potentially reveal novel evolutionary patterns and dynamics. We use bioinformatics, comparative genomics and phylogenetic analyses to show that preproghrelin and prepromotilin descended from a common ancestor and that a gene duplication generated these two genes shortly after the divergence of amphibians and amniotes. The evolutionary history of the receptor family differs from that of their cognate ligands. GPR39 diverges first, and an ancestral receptor gives rise to receptors classified as fish-specific clade A, GHSR and MLNR by successive gene duplications occurring before the divergence of tetrapods and ray-finned fish. The ghrelin/GHSR system is maintained and functionally conserved from fish to mammals. Motilin-MLNR specificity must have arisen by ligand-receptor coevolution after the MLN hormone gene diverged from the GHRL gene in the amniote lineage. Conserved molecular machinery can give rise to new neuroendocrine response mechanisms by the co-option of duplicated genes. Gene duplication is both parsimonious and creative in producing elements for evolutionary tinkering and plays a major role in gene co-option, thus aiding the evolution of greater biological complexity. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of Chi- na (2007CB411600), the National Natural Science Foundation of China (30621092, 30623007), and the Bureau of Science and Technology of Yunnan Province (O803481101). |
| 语种 | 英语 |
| 公开日期 | 2011-09-06 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6753]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Department of Laboratory Medicine and Pathobiology and Banting and Best Diabetes Centre, University of Toronto, Toronto, M5S1A1, Canada 3.Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming 650091, China |
| 推荐引用方式 GB/T 7714 | He J,David IM,Zhang YP[*]. Gene duplication plays a major role in gene co-option: Studies into the evolution of the motilin/ghrelin family and their receptors[J]. CHINESE SCIENCE BULLETIN,2011,56(25):2690-2697. |
| APA | He J,David IM,&Zhang YP[*].(2011).Gene duplication plays a major role in gene co-option: Studies into the evolution of the motilin/ghrelin family and their receptors.CHINESE SCIENCE BULLETIN,56(25),2690-2697. |
| MLA | He J,et al."Gene duplication plays a major role in gene co-option: Studies into the evolution of the motilin/ghrelin family and their receptors".CHINESE SCIENCE BULLETIN 56.25(2011):2690-2697. |
入库方式： OAI收割
来源：昆明动物研究所
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