Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster
文献类型：期刊论文
| 作者 | Gao JJ1; Pan XR1; Hu J1; Ma L1; Wu JM1; Shao YL1; Barton SA2; Woodruff RC3; Zhang YP[*]1,4; Fu YX[*]1,2 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2011 |
| 卷号 | 108期号:38页码:15914-15919 |
| 关键词 | MOUSE |
| 通讯作者 | zhan-gyp@mail.kiz.ac.cn ; yunxin.fu@uth.tmc.edu |
| 英文摘要 | Each cell of higher organism adults is derived from a fertilized egg through a series of divisions, during which mutations can occur. Both the rate and timing of mutations can have profound impacts on both the individual and the population, because mutations that occur at early cell divisions will affect more tissues and are more likely to be transferred to the next generation. Using large-scale multigeneration screening experiments for recessive lethal or nearly lethal mutations of Drosophila melanogaster and recently developed statistical analysis, we show for male D. melanogaster that (i) mutation rates (for recessive lethal or nearly lethal) are highly variable during germ cell development; (ii) first cell cleavage has the highest mutation rate, which drops substantially in the second cleavage or the next few cleavages; (iii) the intermediate stages, after a few cleavages to right before spermatogenesis, have at least an order of magnitude smaller mutation rate; and (iv) spermatogenesis also harbors a fairly high mutation rate. Because germ-line lineage shares some (early) cell divisions with somatic cell lineage, the first conclusion is readily extended to a somatic cell lineage. It is conceivable that the first conclusion is true for most (if not all) higher organisms, whereas the other three conclusions are widely applicable, although the extent may differ from species to species. Therefore, conclusions or analyses that are based on equal mutation rates during development should be taken with caution. Furthermore, the statistical approach developed can be adopted for studying other organisms, including the human germ-line or somatic mutational patterns. |
| 收录类别 | SCI |
| 资助信息 | This work was supported, in part, by grants from the Chinese National Science Foundation (Grant 30570248 to Y.-X.F., Grant 30460026 to J.-J.G., and Grant 30621092 to Y.-P.Z.) and the National Basic Research Program of China (973 Program, Grant 2007CB411600 to Y.-P.Z.), funds from the Bureau of Science and Technology of Yunnan Province of China (to Y.-P.Z.), and the Endowment Fund from the University of Texas (to Y.-X.F.). |
| 语种 | 英语 |
| 公开日期 | 2011-10-10 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6814]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming 650091, Chi 2.Human Genetics Center and Division of Biostatistics, School of Public Health, University of Texas, Houston, TX 77030-3998 3.Department of Biological Science, Bowling Green State University, Bowling Green, OH 43403-0208 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Gao JJ,Pan XR,Hu J,et al. Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(38):15914-15919. |
| APA | Gao JJ.,Pan XR.,Hu J.,Ma L.,Wu JM.,...&Fu YX[*].(2011).Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(38),15914-15919. |
| MLA | Gao JJ,et al."Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.38(2011):15914-15919. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。