The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population
文献类型：期刊论文
| 作者 | Li H1,2; Wang JX3; Wu DD2,4; Wang HW3; Tang NLS[*]4,5,6,7; Zhang YP[*]2,3,4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:1页码:e30268 |
| 通讯作者 | nelsontang@cuhk.edu.hk ; zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | CLEC4M is a C-type lectin gene serving as cell adhesion receptor and pathogen recognition receptor. It recognizes several pathogens of important public health concern. In particular, a highly polymorphic variable number tandem repeat (VNTR) at the neck-region of CLEC4M had been associated with genetic predisposition to some infectious diseases. To gain insight into the origin and evolution of this VNTR in CLEC4M, we studied 21 Africans, 20 Middle Easterns, 35 Europeans, 38 Asians, 13 Oceania, and 18 Americans (a total of 290 chromosomes) from the (Human Genome Diversity Panel) HGDP-CEPH panel; these samples covered most of alleles of this VNTR locus present in human populations. We identified a limited number of haplotypes among the basic repeat subunits that is 69 base pairs in length. Only 8 haplotypes were found. Their sequence identities were determined in the 290 chromosomes. VNTR alleles of different repeat length (from 4 to 9 repeats) were analyzed for composition and orientation of these subunits. Our results showed that the subunit configuration of the same repeat number of VNTR locus from different populations were, in fact, virtually identical. It implies that most of the VNTR alleles existed before dispersion of modern humans outside Africa. Further analyses indicate that the present diversity profile of this locus in worldwide populations is generated from the effect of migration of different tribes and neutral evolution. Our findings do not support the hypothesis that the origin of the VNTR alleles were arisen by independent (separate) mutation events and caused by differential allele advantage and natural selection as suggested by previous report based on SNP data. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from Science and Technology Committee of Yunnan Province, and the National Natural Science Foundation of China (31000955). |
| 语种 | 英语 |
| WOS记录号 | WOS:000299771900054 |
| 公开日期 | 2012-03-20 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6885]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Department of Genetics and Developmental Biology, Southeast University School of Medicine and The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Laboratory for Conservation and Utilization of Bio-resource & Key Laboratory for Microbial Resources of the Ministery of Education, Yunnan University, Kunming, China 4.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 5.Li Ka Shing Institute of Health Sciences and Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China 6.Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China 7.Functional Genomics and Biostatistical Computing laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong China |
| 推荐引用方式 GB/T 7714 | Li H,Wang JX,Wu DD,et al. The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population[J]. PLOS ONE,2012,7(1):e30268. |
| APA | Li H,Wang JX,Wu DD,Wang HW,Tang NLS[*],&Zhang YP[*].(2012).The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population.PLOS ONE,7(1),e30268. |
| MLA | Li H,et al."The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population".PLOS ONE 7.1(2012):e30268. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。