NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons
文献类型：期刊论文
| 作者 | Fu Y1,3; He F3,4,5; Tang NLS2,3; Tam CWC1; Lui VWC1; Chiu HFK1; Lam LCW[*]1 |
| 刊名 | ALZHEIMER DISEASE & ASSOCIATED DISORDERS
 |
| 出版日期 | 2012 |
| 卷号 | 26期号:1页码:88-90 |
| 关键词 | PARKINSONS-DISEASE ASSOCIATION ONSET |
| 通讯作者 | cwlam@cuhk.edu.hk |
| 英文摘要 | Neural precursor cell expressed, developmentally down-regulated (NEDD9) gene was a new candidate risk gene for Alzheimer disease (AD). The CC genotype of a single nucleotide polymorphism rs760678 within this gene was associated with increasing risk of AD in a large study with white population. Our study aimed to replicate the initial report in Chinese population and explore its effect on cognitive performance. A total of 262 patients with AD, 293 patients with mild cognitive impairment, and 434 cognitive intact controls were recruited in the study. The result showed that G allele had a greater risk of AD (chi(2) for trend test = 5.61, df 1, P = 0.018). The effects were mainly observed among Apolipoprotein E (APOE) epsilon 4 noncarriers (chi(2) for trend test = 4.30, df 1, P = 0.038). After adjustment of sex, age, education year, and APOE e4 status by logistic regression, significant association between NEDD9 GG genotype and AD remained [OR = 2.04, 95% confidence interval (CI) = 1.02-4.08, P = 0.044]. The scores of Cantonese version of the Mini-mental State Examination and Alzheimer's Disease Assessment Subscale-Cognitive subscale were associated with N polymorphism after adjusting for sex, age, education year, and ApoE epsilon 4 status (Linear regression model, P < 0.05). Our study identified rs760678 within NEDD9 gene in association with the risk of AD and cognitive performance in Chinese older persons. The fact that different alleles accounted for the risk in different population might suggest that there were ethnic group specific haplotypes that were primarily responsible for the predisposition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300639800013 |
| 公开日期 | 2012-04-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6912]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China 2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Beijing 100864, Peoples R China 5.KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu Y,He F,Tang NLS,et al. NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS,2012,26(1):88-90. |
| APA | Fu Y.,He F.,Tang NLS.,Tam CWC.,Lui VWC.,...&Lam LCW[*].(2012).NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons.ALZHEIMER DISEASE & ASSOCIATED DISORDERS,26(1),88-90. |
| MLA | Fu Y,et al."NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons".ALZHEIMER DISEASE & ASSOCIATED DISORDERS 26.1(2012):88-90. |
入库方式： OAI收割
来源：昆明动物研究所
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