Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome
文献类型：期刊论文
| 作者 | Liu J1,2,3; Wang LD4; Sun YB1,2,3; Li EM5; Xu LY5; Zhang YP1,2,6; Yao YG7; Kong QP[*]1,2 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2012 |
| 卷号 | 29期号:4页码:1255-1261 |
| 关键词 | cancer mitochondrial genome somatic mutation selective constraints |
| 通讯作者 | kongqp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | In accordance with the hypothesis that cancer formation is a process of somatic evolution driven by natural selection, signature of positive selection has been detected on a number of cancer-related nuclear genes. It remains, however, controversial whether a similar selective pressure has also acted on mitochondrial DNA (mtDNA), a small molecule in mitochondrion that may play an important role in tumorigenesis by altering oxidative phosphorylation. To better understand the mutational pattern on cancerous mtDNA and decipher the genetic signature left by natural selection, a total of 186 entire mitochondrial genomes of cancerous and adjacent normal tissues from 93 esophageal cancer patients were obtained and extensively studied. Our results revealed that the observed mutational pattern on the cancerous mtDNAs might be best explained as relaxation of negative selection. Taking into account an additional 1,235 cancerous (nearly) complete mtDNA sequences retrieved from the literature, our results suggested that the relaxed selective pressure was the most likely explanation for the accumulation of mtDNA variation in different types of cancer. This notion is in good agreement with the observation that aerobic glycolysis, instead of mitochondrial respiration, plays the key role in generating energy in cancer cells. Furthermore, our study provided solid evidence demonstrating that problems in some of the published cancerous mtDNA data adequately explained the previously contradictory conclusions about the selective pressure on cancer mtDNA, thus serving as a paradigm emphasizing the importance of data quality in affecting our understanding on the role of mtDNA in tumorigenesis. |
| 资助信息 | This work was supported by grants from the Chinese AcademyofSciences(KSCXZ-EW-J-23),Scienceand Tech- nologyBureauof Kunming(08H130301),NationalNatural Science Foundation of China (30900797 and 30925021), and Yunnan Province (2009CI119). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000302018100014 |
| 公开日期 | 2012-05-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6927]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_重大疾病机理的遗传学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China 4.Henan Key Laboratory for Esophageal Cancer Research, Department of Basic Oncology and Pathology at College of Medicine, The First and The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, China 5.Department of Biochemistry, Medical College of Shantou University, Shantou, China 6.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 7.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Liu J,Wang LD,Sun YB,et al. Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(4):1255-1261. |
| APA | Liu J.,Wang LD.,Sun YB.,Li EM.,Xu LY.,...&Kong QP[*].(2012).Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome.MOLECULAR BIOLOGY AND EVOLUTION,29(4),1255-1261. |
| MLA | Liu J,et al."Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome".MOLECULAR BIOLOGY AND EVOLUTION 29.4(2012):1255-1261. |
入库方式： OAI收割
来源：昆明动物研究所
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