Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes
文献类型：期刊论文
| 作者 | Wang HW1,2; Li YC1; Sun F3; Zhao M1,4; Mitra B2,5; Chaudhuri TK5; Regmi P6; Wu SF1,4; Kong QP[*]1,4; Zhang YP[*]1,2,4 |
| 刊名 | JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2012 |
| 卷号 | 57期号:4页码:228-234 |
| 关键词 | mtDNA Nepalese origin |
| 通讯作者 | kongqp@yahoo.com.cn ; zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Himalayas was believed to be a formidably geographical barrier between South and East Asia. The observed high frequency of the East Eurasian paternal lineages in Nepal led some researchers to suggest that these lineages were introduced into Nepal from Tibet directly; however, it is also possible that the East Eurasian genetic components might trace their origins to northeast India where abundant East Eurasian maternal lineages have been detected. To trace the origin of the Nepalese maternal genetic components, especially those of East Eurasian ancestry, and then to better understand the role of the Himalayas in peopling Nepal, we have studied the matenal genetic composition extensively, especially the East Eurasian lineages, in Nepalese and its surrounding populations. Our results revealed the closer affinity between the Nepalese and the Tibetans, specifically, the Nepalese lineages of the East Eurasian ancestry generally are phylogenetically closer with the ones from Tibet, albeit a few mitochondrial DNA haplotypes, likely resulted from recent gene flow, were shared between the Nepalese and northeast Indians. It seems that Tibet was most likely to be the homeland for most of the East Eurasian in the Nepalese. Taking into account the previous observation on Y chromosome, now it is convincing that bearer of the East Eurasian genetic components had entered Nepal across the Himalayas around 6 kilo years ago (kya), a scenario in good agreement with the previous results from linguistics and archeology |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Natural Science Foundation of Yunnan Province (No. 2011FB106) and the National Natural Science Foundation of China (NSFC, Nos. 30900797 and 30621092). |
| 语种 | 英语 |
| WOS记录号 | WOS:000303416800002 |
| 公开日期 | 2012-05-31 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6960]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子人类学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China 2.Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, PR China 3.Department of Parasitology, Medical Teaching Institute, Xinxiang Medical University, Xinxiang, China 4.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 5.Cellular Immunology Laboratory, Department of Zoology, University of North Bengal Siliguri, Siliguri, India 6.Little Angel’s College Hattiban, Lalitpur, Nepal |
| 推荐引用方式 GB/T 7714 | Wang HW,Li YC,Sun F,et al. Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes[J]. JOURNAL OF HUMAN GENETICS,2012,57(4):228-234. |
| APA | Wang HW.,Li YC.,Sun F.,Zhao M.,Mitra B.,...&Zhang YP[*].(2012).Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes.JOURNAL OF HUMAN GENETICS,57(4),228-234. |
| MLA | Wang HW,et al."Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes".JOURNAL OF HUMAN GENETICS 57.4(2012):228-234. |
入库方式： OAI收割
来源：昆明动物研究所
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