Novel coding genetic variants of the GBP1 gene in wild and domestic pigs (Sus scrofa)
文献类型：期刊论文
| 作者 | Chen SY1; Gomes R1; Costa V1; Rocha I1; Zsolnai A2,3; Anton I2; Charneca R4; Santos P4; Nunes JL4; Buzgo J5 |
| 刊名 | LIVESTOCK SCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 146期号:1页码:1-4 |
| 关键词 | Domestic pig Wild boar GBP1 Genetic variability SNP Rare alleles |
| 通讯作者 | albanobp@fc.up.pt |
| 合作状况 | 其它 |
| 英文摘要 | The interferon-induced guanylate-binding protein 1 gene (GBP1) plays an important role in host defense against viral, bacterial and protozoan infections. To explore novel genetic variants in this gene, we re-sequenced a 587-bp fragment spanning the exon 2 of the GBP1 gene in a sample panel consisting of 34 wild boars and 59 local domestic pigs from three geographic regions (China, Iberian Peninsula, and Central Europe) and 12 individuals of three commercial breeds (Pietrain, Landrace, and Large White). In a final 543-bp sequence fragment, there were 14 single nucleotide polymorphisms (SNPs), of which five were coding (three novel mutations). A total of 19 haplotypes were reconstructed and most haplotypes were shared by two or more sample groups. Those shared haplotypes revealed a clear signature of genetic introgression from Chinese domestic pigs into European domestic pigs. In addition, there were six haplotypes with frequencies below 1%, but none of them were present in the three commercial breeds (Pietrain. Landrace, and Large White). Although a limited number of individuals and breeds were analyzed, the absence of rare alleles (or haplotypes) in the commercial breeds is an indication that a significant proportion of genetic diversity in domestic species is not present in commercial breeds. This study demonstrated the potential to find sufficient genetic variation for population genetic analyses of demography versus selection, in functional candidate genes of domestic pigs and wild boars worldwide. |
| 资助信息 | This work was funded by Fundação para a Ciência e Tecnologia (FCT) project PTDC/CVT/68907/2006 (AB-P). SC is supported by a FCT individual fellowship grant SFRH/BPD/46082/2008. We thank Vlado Margeta for his help in sampling Hungary Black Slavonian breed. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303971800001 |
| 公开日期 | 2012-09-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7077]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Centro de Investigação em Biodiversidade e Recursos Genéticos da Universidade do Porto (CIBIO-UP), Rua Padre Armando Quintas 7, 4485-661 Vairão, Portugal 2.Research Institute for Animal Breeding and Nutrition, H-2053 Herceghalom, Hungary 3.University of Kaposvár, H-7400, Kaposvár, Hungary 4.ICAAM - Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Universidade de Évora, Herdade da Mitra, 7002-554 Évora, Portugal 5.SEFAG Forest Management and Wood Industry Share Company, Kaposvár, Hungary 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Chen SY,Gomes R,Costa V,et al. Novel coding genetic variants of the GBP1 gene in wild and domestic pigs (Sus scrofa)[J]. LIVESTOCK SCIENCE,2012,146(1):1-4. |
| APA | Chen SY.,Gomes R.,Costa V.,Rocha I.,Zsolnai A.,...&Beja-Pereira A[*].(2012).Novel coding genetic variants of the GBP1 gene in wild and domestic pigs (Sus scrofa).LIVESTOCK SCIENCE,146(1),1-4. |
| MLA | Chen SY,et al."Novel coding genetic variants of the GBP1 gene in wild and domestic pigs (Sus scrofa)".LIVESTOCK SCIENCE 146.1(2012):1-4. |
入库方式： OAI收割
来源：昆明动物研究所
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