Lactase persistence may have an independent origin in Tibetan populations from Tibet, China
文献类型：期刊论文
| 作者 | Peng MS1,3; He JD1,2,3; Zhu CL1,3; Wu SF1,3; Jin JQ1,3; Zhang YP[*]1,3,4 |
| 刊名 | JOURNAL OF HUMAN GENETICS
 |
| 出版日期 | 2012 |
| 卷号 | 57期号:6页码:394-397 |
| 关键词 | culture genetic diversity lactase persistence milk SNP Tibetan Tibet |
| 通讯作者 | zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Milk consumption is prevalent in daily diets of Tibetans. To digest the milk sugar lactose, lactase persistence (LP) should be required. However, little is known about the genetic basis of LP in Tibetans. We screened 495 Tibetan individuals for five previously reported single-nucleotide polymorphisms (SNPs): -13907C/G (rs41525747), -13910C/T (rs4988235), -13915T/G (rs41380347), -14010G/C and -22018G/A (rs182549), which are associated with the LP in populations from a vast region surrounding Tibet. The five SNPs were nearly absent in Tibetan populations, suggesting LP likely to have an independent origin in Tibetans rather than to be introduced via gene flow from neighboring populations. We identified three novel SNPs (-13838G/A, -13906T/A and -13908C/T) in Tibetans. In particular, -13838G/A might be functional as it is located in the binding motif for HNF4 alpha that acts as a transcription factor for intestinal gene expression. To investigate the potential association of this variant with LP, further detailed studies are required in the future. Journal of Human Genetics (2012) 57, 394-397; doi:10.1038/jhg.2012.41; published online 10 May 2012 |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from National Natural Science Foundation of China and Bureau of Science and Technology of Yunnan Province. |
| 语种 | 英语 |
| WOS记录号 | WOS:000305808500011 |
| 公开日期 | 2013-05-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7421]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_两栖爬行类多样性与进化 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, China 3.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China 4.Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Peng MS,He JD,Zhu CL,et al. Lactase persistence may have an independent origin in Tibetan populations from Tibet, China[J]. JOURNAL OF HUMAN GENETICS,2012,57(6):394-397. |
| APA | Peng MS,He JD,Zhu CL,Wu SF,Jin JQ,&Zhang YP[*].(2012).Lactase persistence may have an independent origin in Tibetan populations from Tibet, China.JOURNAL OF HUMAN GENETICS,57(6),394-397. |
| MLA | Peng MS,et al."Lactase persistence may have an independent origin in Tibetan populations from Tibet, China".JOURNAL OF HUMAN GENETICS 57.6(2012):394-397. |
入库方式： OAI收割
来源：昆明动物研究所
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