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Lack of association between STK39 and hypertension in the Chinese population

文献类型：期刊论文

作者Xu J1,2; Ji LD1,3; Zhang LN2; Dong CZ2; Fei LJ2; Hua S1; Tsai JY4; Zhang YP[*]1,5
刊名JOURNAL OF HUMAN HYPERTENSION
出版日期2013
卷号27期号:5页码:294-297
关键词genome-wide association study serine/threonine kinase 39 polymorphism interaction
通讯作者zhangyp@mail.kiz.ac.cn
合作状况其它
英文摘要Genome-wide association study (GWAS) has identified serine/threonine kinase 39 (STK39) as a candidate gene for hypertension. A replication study provided supporting evidence that STK39 functional polymorphism rs35929607 was associated with hypertension. Recently, another study also showed rs6749447 within the STK39 was associated with blood pressure responses. However, these studies were all conducted in Caucasians. Thus, we carried out a case-control study to test whether STK39 is a common candidate gene for hypertension, and to examine the interaction of genetic factors and non-genetic risk factors in the Chinese population. Thousand twenty four hypertensive cases and 1024 controls were genotyped for five polymorphisms. Four single-nucleotide polymorphisms (SNPs) are located within STK39, and rs4977950, the SNP that showed the strongest signal is located in a gene desert. Results indicated that none of these SNPs was associated with hypertension in the Chinese population. Logistic regression analysis found body mass index (BMI) and triglyceride level were higher in the hypertension group when compared with the control group. Multifactor dimensionality reduction analysis indicated that the interaction between BMI and rs4977950 may have an impact on hypertension. Taken together, the present study found no evidence that STK39 was associated with hypertension in the Chinese population. Instead, non-genetic risk factors such as BMI have an important role in Chinese hypertensive subjects, and the 'missing inheritability' requires further investigation.
收录类别SCI
资助信息This study was supported by Zhejiang Natural Science Foundation (Y2100857), Ningbo Natural Science Foundation (2011A610037, 2012A610237) and China Postdoctoral Science Foundation (20100481399).
语种英语
WOS记录号WOS:000317483000003
公开日期2013-05-17
源URL[http://159.226.149.42:8088/handle/152453/7424]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
2.Department of Public Health, School of Medicine, Ningbo University, Ningbo, China
3.Institute of Biochemistry, School of Medicine, Ningbo University, Ningbo, China
4.Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
5.Laboratory for Conservation and Utilization of Bio- resource, Yunnan University, Kunming, China
推荐引用方式
GB/T 7714		 Xu J,Ji LD,Zhang LN,et al. Lack of association between STK39 and hypertension in the Chinese population[J]. JOURNAL OF HUMAN HYPERTENSION,2013,27(5):294-297.
APA Xu J.,Ji LD.,Zhang LN.,Dong CZ.,Fei LJ.,...&Zhang YP[*].(2013).Lack of association between STK39 and hypertension in the Chinese population.JOURNAL OF HUMAN HYPERTENSION,27(5),294-297.
MLA Xu J,et al."Lack of association between STK39 and hypertension in the Chinese population".JOURNAL OF HUMAN HYPERTENSION 27.5(2013):294-297.

入库方式： OAI收割

来源：昆明动物研究所

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