Natural selection and adaptive evolution of leptin
文献类型：期刊论文
| 作者 | Zou G1; Zhang YP1,3; Yu L[*]1,2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2013 |
| 卷号 | 58期号:18页码:2104-2112 |
| 关键词 | natural selection adaptive evolution leptin leptin receptor |
| 通讯作者 | yuli1220@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | Leptin is an adiposity-secreted hormone that is pivotal in regulating feeding behavior, energy metabolism and body mass. The study of leptin has been of crucial importance for public health and pharmaceutical intervention given its role in obesity. Generally, leptin is highly conserved due to its functional importance. However, episodes of rapid sequence evolution and positive selection have been observed in some mammalian species, indicating that the leptin functions in these animals may have undergone adaptive modification to their environments. In this article, we review the adaptive evolution of leptin and its potential functional consequences. This review is expected to guide future research of molecular evolution and functional assays of this gene, and also to provide a theoretical foundation for the use of leptin in therapeutic applications. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Natural Science Foundation of China (U0836603) and Program for New Century Excellent Talents in University (NCET). |
| 语种 | 英语 |
| WOS记录号 | WOS:000321629800003 |
| 公开日期 | 2013-08-27 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7597]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 2.Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming 650091, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zou G,Zhang YP,Yu L[*]. Natural selection and adaptive evolution of leptin[J]. CHINESE SCIENCE BULLETIN,2013,58(18):2104-2112. |
| APA | Zou G,Zhang YP,&Yu L[*].(2013).Natural selection and adaptive evolution of leptin.CHINESE SCIENCE BULLETIN,58(18),2104-2112. |
| MLA | Zou G,et al."Natural selection and adaptive evolution of leptin".CHINESE SCIENCE BULLETIN 58.18(2013):2104-2112. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。