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Artificial Selection on Brain-Expressed Genes during the Domestication of Dog

文献类型：期刊论文

作者Li Y1,2; vonHoldt BM3; Reynolds A4; Boyko AR5; Wayne RK6; Wu DD[*]2; Zhang YP[*]1,2
刊名MOLECULAR BIOLOGY AND EVOLUTION
出版日期2013
卷号30期号:8页码:1867–1876
关键词artificial selection dog domestication brain evolution behavioral evolution
通讯作者wudongdong@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn
合作状况其它
英文摘要Domesticated dogs have many unique behaviors not found in gray wolves that have augmented their interaction and communication with humans. The genetic basis of such unique behaviors in dogs remains poorly understood. We found that genes within regions highly differentiated between outbred Chinese native dogs (CNs) and wolves show high bias for expression localized to brain tissues, particularly the prefrontal cortex, a specific region responsible for complex cognitive behaviors. In contrast, candidate genes showing high population differentiation between CNs and German Shepherd dogs (GSs) did not demonstrate significant expression bias. These observations indicate that these candidate genes highly expressed in the brain have rapidly evolved. This rapid evolution was probably driven by artificial selection during the primary transition from wolves to ancient dogs and was consistent with the evolution of dog-specific characteristics, such as behavior transformation, for thousands of years.
收录类别SCI
资助信息This work was supported by grants from the National Basic Research Program of China (973 Program, Grant 2007CB815702), National Natural Science Foundation of China (31061160189), and the National Science Foundation (US) to R.K.W. (for the wolf SNP genotyping).
语种英语
WOS记录号WOS:000321820400012
公开日期2013-08-28
源URL[http://159.226.149.42:8088/handle/152453/7610]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
昆明动物研究所_进化与发育转录组学
作者单位1.Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming, China
2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
3.Department of Ecology and Evolutionary Biology, University of California, Irvine
4.Department of Biological Statistics and Computational Biology, Cornell University
5.Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University
6.Department of Ecology and Evolutionary Biology, University of California, Los Angeles
推荐引用方式
GB/T 7714		 Li Y,vonHoldt BM,Reynolds A,et al. Artificial Selection on Brain-Expressed Genes during the Domestication of Dog[J]. MOLECULAR BIOLOGY AND EVOLUTION,2013,30(8):1867–1876.
APA Li Y.,vonHoldt BM.,Reynolds A.,Boyko AR.,Wayne RK.,...&Zhang YP[*].(2013).Artificial Selection on Brain-Expressed Genes during the Domestication of Dog.MOLECULAR BIOLOGY AND EVOLUTION,30(8),1867–1876.
MLA Li Y,et al."Artificial Selection on Brain-Expressed Genes during the Domestication of Dog".MOLECULAR BIOLOGY AND EVOLUTION 30.8(2013):1867–1876.

入库方式： OAI收割

来源：昆明动物研究所

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