The Motilin Gene Evolved a New Function in Kangaroo Rats and Kangaroo Mice (Dipodomyinae)
文献类型：期刊论文
| 作者 | He J1,2; Zhou TC3; Irwin DM1,4; Shen YY1,2; Zhang YP[*]1,2,3 |
| 刊名 | JOURNAL OF MOLECULAR EVOLUTION
 |
| 出版日期 | 2012 |
| 卷号 | 75期号:3-4页码:112-118 |
| 关键词 | Gene loss Ortholog Functional evolutionary shift Interaction network |
| 通讯作者 | zhangyp1@263.net.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The motilin receptor gene was lost in the ancestral lineage of rodents. Subsequently, the gene encoding its ligand, motilin, has experienced different evolutionary fates. Previous genomic analyses had shown that the motilin gene (MLN) became a pseudogene independently in the lineages leading to the guinea pig and the common ancestor of the mouse and rat, yet an intact, and thus potentially functional, open reading frame for the MLN was preserved in the Dipodomys ordii genome. As only a single MLN haplotype from D. ordii was available, and this sequence is from a low coverage draft genome, it is possible that the intact MLN found in the draft kangaroo rat genome is an artifact, or represents an intermediate in the process of becoming a pseudogene. In order to establish whether an intact MLN is retained in kangaroo rats despite the loss of its specific receptor, and to investigate the evolutionary mechanisms underlying the retention of this gene sequence, we isolated MLN sequences from species that represent the diversity of the Dipodomyinae [the monophyletic Dipodomyinae subfamily consists of two genera: Dipodomys (kangaroo rats) and Microdipodops (kangaroo mice)]. The results demonstrate that the MLN sequence is well conserved in Dipodomyinae, and it codes for a predicted motilin peptide sequence possessing a conserved N-terminal pharmacophore and the potential to be processed and secreted as a hormone. The observations that the MLN evolved as a functional gene during the radiation of the Dipodomyinae, species that have lost their original motilin receptor, suggest that the MLN has undergone a lineage-specific physiological adaptation to a new function. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Grants from the National Natural Science Foundation of China (30621092, 30623007, 31061160189), and Bureau of Science and Technology of Yunnan Province (O803481101). |
| 语种 | 英语 |
| WOS记录号 | WOS:000312262600004 |
| 公开日期 | 2013-09-16 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7637]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming 650223, Yunnan, China 2.Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming 650091, Yunnan, China 4.Department of Laboratory Medicine and Pathobiology and Banting and Best Diabe |
| 推荐引用方式 GB/T 7714 | He J,Zhou TC,Irwin DM,et al. The Motilin Gene Evolved a New Function in Kangaroo Rats and Kangaroo Mice (Dipodomyinae)[J]. JOURNAL OF MOLECULAR EVOLUTION,2012,75(3-4):112-118. |
| APA | He J,Zhou TC,Irwin DM,Shen YY,&Zhang YP[*].(2012).The Motilin Gene Evolved a New Function in Kangaroo Rats and Kangaroo Mice (Dipodomyinae).JOURNAL OF MOLECULAR EVOLUTION,75(3-4),112-118. |
| MLA | He J,et al."The Motilin Gene Evolved a New Function in Kangaroo Rats and Kangaroo Mice (Dipodomyinae)".JOURNAL OF MOLECULAR EVOLUTION 75.3-4(2012):112-118. |
入库方式： OAI收割
来源：昆明动物研究所
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