Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population
文献类型：期刊论文
| 作者 | Ji LD1,2; Cai XB1; Zhang LN3; Fei LJ3; Wang L4; Su J5; Lazar L3; Xu J[*]3; Zhang YP[*]2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:8页码:e72701 |
| 通讯作者 | xujin1@nbu.edu.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Renin-angiotensin-aldosterone system (RAAS) is the most important endocrine blood pressure control mechanism in our body, genes encoding components of this system have been strong candidates for the investigation of the genetic basis of hypertension. However, previous studies mainly focused on limited polymorphisms, thus we carried out a case-control study in the Han Chinese population to systemically investigate the association between polymorphisms in the RAAS genes and essential hypertension. Methods: 905 essential hypertensive cases and 905 normotensive controls were recruited based on stringent inclusion and exclusion criteria. All 41 tagSNPs within RAAS genes were retrieved from HapMap, and the genotyping was performed using the GenomeLab SNPstream Genotyping System. Logistic regression analysis, Multifactor dimensionality reduction (MDR), stratified analysis and crossover analysis were used to identify and characterize interactions among the SNPs and the non-genetic factors. Results: Serum levels of total cholesterol (TC) and triglyceride (TG), and body mass index (BMI) were significantly higher in the hypertensive group than in the control group. Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension. The MDR analysis demonstrated that the interaction between BMI and rs4305 increased the susceptibility to hypertension. Crossover analysis and stratified analysis further indicated that BMI has a major effect, and rs4305 has a minor effect. Conclusion: These novel findings indicated that together with non-genetic factors, these genetic variants in the RAAS may play an important role in determining an individual's susceptibility to hypertension in the Han Chinese. |
| 收录类别 | SCI |
| 资助信息 | This study was financially supported by Zhejiang Natural Science Foundation (LQ13C060001), Ningbo Natural Science Foundation (2012A610237), Research Project of Zhejiang Education Department (Y201224146), as well as the KC Wong Magna Fund in Ningbo University. |
| 语种 | 英语 |
| WOS记录号 | WOS:000323733800074 |
| 公开日期 | 2013-09-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7687]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, China 4.Department of Pathology, School of Medicine, Ningbo University, Ningbo, China 5.Department of Cardiology, The Affiliated Ningbo No.1 Hospital, School of Medicine, Ningbo University, Ningbo, China |
| 推荐引用方式 GB/T 7714 | Ji LD,Cai XB,Zhang LN,et al. Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population[J]. PLOS ONE,2013,8(8):e72701. |
| APA | Ji LD.,Cai XB.,Zhang LN.,Fei LJ.,Wang L.,...&Zhang YP[*].(2013).Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population.PLOS ONE,8(8),e72701. |
| MLA | Ji LD,et al."Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population".PLOS ONE 8.8(2013):e72701. |
入库方式： OAI收割
来源：昆明动物研究所
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