Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese
文献类型：期刊论文
| 作者 | Yang XY1,2; Wu WJ1; Yang C2; Yang T1; He JD3; Yang ZQ1; He L[*]1 |
| 刊名 | DERMATOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 227期号:3页码:202-208 |
| 关键词 | Acne vulgaris Androgens HSD17B3 HSD3B1 Single-nucleotide polymorphisms |
| 通讯作者 | heli2662@yahoo.com.cn |
| 英文摘要 | Acne vulgaris is a very common skin disorder. Previous studies have indicated that genetic background factors play key roles in the onset of acne. Our previous investigation implicated several genes in the androgen metabolism pathway with acne vulgaris in the Han Chinese population. Thus, we further investigated genes and genetic variants that play important roles in this pathway for their relationship with the pathology of acne. In this study, a total of 610 subjects, including 403 acne patients and 207 healthy controls, were genotyped for 15 single-nucleotide polymorphisnns in HSD3B1 and HSD17B3 genes. This study shows that rs6428829 in HSD3B1 was associated with acne vulgaris in Han patients from Southwest China, even after adjusting for age and sex. The GG genotype was associated with an increased risk of acne vulgaris (p < 0.05) and G allele carriers were associated with an increased risk of acne vulgaris (p < 0.05). In addition, the haplotype AAT in HSD3B1 significantly increased the risk of acne vulgaris in the case-control study (p < 0.05). Furthermore, for another gene in this pathway, HSD17B3, the haplotype H8 was significantly associated with an increased risk of acne vulgaris. Based on these analyses, our study indicates that the cutaneous androgen metabolism-regulated genes HSD3B1 and HSD17B3 increase the susceptibility to acne vulgaris in Han Chinese from Southwest China. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327675500003 |
| 公开日期 | 2013-12-23 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7747]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province, Kunming 650032, China 2.Winona Dermo-Cosmetology Center 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Yang XY,Wu WJ,Yang C,et al. Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese[J]. DERMATOLOGY,2013,227(3):202-208. |
| APA | Yang XY.,Wu WJ.,Yang C.,Yang T.,He JD.,...&He L[*].(2013).Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese.DERMATOLOGY,227(3),202-208. |
| MLA | Yang XY,et al."Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese".DERMATOLOGY 227.3(2013):202-208. |
入库方式： OAI收割
来源：昆明动物研究所
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