Evolutionary perspective on hepatitis B virus with an expanded sampling strategy
文献类型：期刊论文
| 作者 | He JD1; Gao JM1; Shen T1; Murphy RW2,3; Yan XM[*]1 |
| 刊名 | VIRUS RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 178期号:2页码:525-529 |
| 关键词 | Evolution HBeAg Sampling strategy |
| 通讯作者 | yxmin08@163.com |
| 合作状况 | 其它 |
| 英文摘要 | To investigate the role hepatitis Be antigen (HBeAg) plays in the evolution of hepatitis B virus (HBV), we sequenced the basic core promoter (BCP) and precore (preC) regions of 348 clones total from ten HBV Chinese patients. Eleven mutations were more frequent in HBeAg-negative patients than in HBeAg-positive patients. Further, the sequencing of dozens of variants was found to be necessary to obtain mutation profiles. Phylogenetic and median-joining network analyses suggested that variants from each patient had a single common ancestor (monophyly). Higher haplotype and nucleotide diversities were identified in HBeAg-negative"patients. Analysis of dNIdS suggested that viruses experiencing a stronger immune response had lower haplotype diversity. Because HBeAg seroconversion was associated with viral diversity it served as an indicator of HBV evolution. Significantly, this study indicated a larger sampling of variants from each patient was required to understand effectively the properties of HBV. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329266300043 |
| 公开日期 | 2014-02-11 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7796]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Institute of Clinical and Basic Medical Sciences, Center of Clinical Molecular Biology, Key Laboratory for Birth Defects and Genetic Diseases, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, Canada |
| 推荐引用方式 GB/T 7714 | He JD,Gao JM,Shen T,et al. Evolutionary perspective on hepatitis B virus with an expanded sampling strategy[J]. VIRUS RESEARCH,2013,178(2):525-529. |
| APA | He JD,Gao JM,Shen T,Murphy RW,&Yan XM[*].(2013).Evolutionary perspective on hepatitis B virus with an expanded sampling strategy.VIRUS RESEARCH,178(2),525-529. |
| MLA | He JD,et al."Evolutionary perspective on hepatitis B virus with an expanded sampling strategy".VIRUS RESEARCH 178.2(2013):525-529. |
入库方式： OAI收割
来源：昆明动物研究所
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