Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne
文献类型：期刊论文
| 作者 | He L[*]1; Wu WJ1; Yang JK2,3; Cheng H4,5; Zuo XB4,5; Lai W6; Gao TW7; Ma CL7; Luo N8; Huang JQ9 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:X页码:e2870 |
| 通讯作者 | helikm2662@126.com ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, P-combined 4.41 x 10(-9) and rs1060573, Pcombined 1.28 x 10(-8)) and 1q24.2 (SELL, rs7531806, P-combined 1.20 x 10(-8)) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the National Natural Science Foundation of China (81060123, 31000528), the Yunnan Natural Science Foundation(2011FA028, 2011FB175, 2012FB004), R&D Infrastructure and Facility Development Programme of Yunnan Province (2011-307). |
| 语种 | 英语 |
| WOS记录号 | WOS:000344332600183 |
| 公开日期 | 2014-03-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7812]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province, Kunming 650032, China 2.Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, China 3.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei 230032, China 5.Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei 230032, China 6.Department of Dermatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China 7.Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China 8.Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China 9.Fuzhou Dermatosis Prevention Hospital, Fuzhou 350025, China 10.Department of Dermatology, Kunming Medical University Affiliated Hospital Qujing (Qujing First People’s Hospital), Qujing 655000, China |
| 推荐引用方式 GB/T 7714 | He L[*],Wu WJ,Yang JK,et al. Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne[J]. NATURE COMMUNICATIONS,2014,5(X):e2870. |
| APA | He L[*].,Wu WJ.,Yang JK.,Cheng H.,Zuo XB.,...&Zhang YP[*].(2014).Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.NATURE COMMUNICATIONS,5(X),e2870. |
| MLA | He L[*],et al."Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne".NATURE COMMUNICATIONS 5.X(2014):e2870. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。