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Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs
文献类型：期刊论文
| 作者 | Li Y1,2; Wu DD[*]1,2; Boyko AR3; Wang GD[1]1,2; Wu SF1; Irwin DM1,4,5; Zhang YP[*]1,2,6 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:5页码:1200-1205 |
| 关键词 | high-altitude adaptation Tibetan Mastiff domestication |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; zhangyp@ mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | With the assistance of their human companions, dogs have dispersed into new environments during the expansion of human civilization. Tibetan Mastiff (TM), a native of the Tibetan Plateau, was derived from the domesticated Chinese native dog and, like Tibetans, has adapted to the extreme environment of high altitude. Here, we genotyped genome-wide single-nucleotide polymorphisms (SNPs) from 32 TMs and compared them with SNPs from 20 Chinese native dogs and 14 gray wolves (Canis lupus). We identified 16 genes with signals of positive selection in the TM, with 12 of these candidate genes associated with functions that have roles in adaptation to high-altitude adaptation, such as EPAS1, SIRT7, PLXNA4, and MAFG that have roles in responses to hypoxia. This study provides important information on the genetic diversity of the TM and potential mechanisms for adaptation to hypoxia. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (31321002, 91231108, 31123005), and the 973 program (2013CB835200). |
| 语种 | 英语 |
| WOS记录号 | WOS:000335914400012 |
| 公开日期 | 2014-06-03 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7851]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University 4.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada 5.Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada 6.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Li Y,Wu DD[*],Boyko AR,et al. Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs[J]. MOLECULAR BIOLOGY AND EVOLUTION,2014,31(5):1200-1205. |
| APA | Li Y.,Wu DD[*].,Boyko AR.,Wang GD[1].,Wu SF.,...&Zhang YP[*].(2014).Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs.MOLECULAR BIOLOGY AND EVOLUTION,31(5),1200-1205. |
| MLA | Li Y,et al."Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs".MOLECULAR BIOLOGY AND EVOLUTION 31.5(2014):1200-1205. |
入库方式： OAI收割
来源：昆明动物研究所
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