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Pattern of Mutation Rates in the Germline of Drosophila melanogaster Males from a Large-Scale Mutation Screening Experiment

文献类型：期刊论文

作者Gao JJ1; Pan XR1; Hu J1; Ma L1; Wu JM1; Shao YL1; Ai SM1; Liu SQ1; Barton SA2; Woodruff RC3
刊名G3-GENES GENOMES GENETICS
出版日期2014
卷号4期号:8页码:1503-1514
关键词germline mutation rate likelihood inference Drosophila melanogaste cell coalescent
通讯作者yunxin.fu@uth.tmc.edu
合作状况其它
英文摘要The sperm or eggs of sexual organisms go through a series of cell divisions from the fertilized egg; mutations can occur at each division. Mutations in the lineage of cells leading to the sperm or eggs are of particular importance because many such mutations may be shared by somatic tissues and also may be inherited, thus having a lasting consequence. For decades, little has been known about the pattern of the mutation rates along the germline development. Recently it was shown from a small portion of data that resulted from a large-scale mutation screening experiment that the rates of recessive lethal or nearly lethal mutations differ dramatically during the germline development of Drosophila melanogaster males. In this paper the full data set from the experiment and its analysis are reported by taking advantage of a recent methodologic advance. By analyzing the mutation patterns with different levels of recessive lethality, earlier published conclusions based on partial data are found to remain valid. Furthermore, it is found that for most nearly lethal mutations, the mutation rate at the first cell division is even greater than previous thought compared with those at other divisions. There is also some evidence that the mutation rate at the second division decreases rapidly but is still appreciably greater than those for the rest of the cleavage stage. The mutation rate at spermatogenesis is greater than late cleavage and stem-cell stages, but there is no evidence that rates are different among the five cell divisions of the spermatogenesis. We also found that a modestly biased sampling, leading to slightly more primordial germ cells after the eighth division than those reported in the literature, provides the best fit to the data. These findings provide conceptual and numerical basis for exploring the consequences of differential mutation rates during individual development.
收录类别SCI
资助信息This work was partly support by grants from the Chinese NSF (30570248 and 91231120 YF) and the Betty Wheless Trotter Endowment Fund from The University of Texas Health Science Center at Houston, TX.
语种英语
WOS记录号WOS:000341013200013
公开日期2014-10-10
源URL[http://159.226.149.42:8088/handle/152453/8025]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan, China
2.Division of Biostatistics and Human Genetics Center, School of Public Health, The University of Texas at Houston, Houston, Texas,
3.Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio
4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式
GB/T 7714		 Gao JJ,Pan XR,Hu J,et al. Pattern of Mutation Rates in the Germline of Drosophila melanogaster Males from a Large-Scale Mutation Screening Experiment[J]. G3-GENES GENOMES GENETICS,2014,4(8):1503-1514.
APA Gao JJ.,Pan XR.,Hu J.,Ma L.,Wu JM.,...&Fu YX[*].(2014).Pattern of Mutation Rates in the Germline of Drosophila melanogaster Males from a Large-Scale Mutation Screening Experiment.G3-GENES GENOMES GENETICS,4(8),1503-1514.
MLA Gao JJ,et al."Pattern of Mutation Rates in the Germline of Drosophila melanogaster Males from a Large-Scale Mutation Screening Experiment".G3-GENES GENOMES GENETICS 4.8(2014):1503-1514.

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来源：昆明动物研究所

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