Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population
文献类型：期刊论文
| 作者 | Zhang LN1; Ji LD2,3; Fei LJ1; Yuan F1; Zhang YM1; Xu J[*]1,3 |
| 刊名 | BioMed research international
 |
| 出版日期 | 2013 |
| 卷号 | 2013期号:X页码:e451094 |
| 通讯作者 | xujin1@nbu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | The association between polymorphisms of alpha-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected. Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer. All 6 tag single nucleotide polymorphisms (tagSNPs) within ADD1 gene were genotyped by SNPstream genotyping system. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the SNPs and the non-genetic factors. Results showed that plasma triglyceride, total cholesterol, and BMI were significantly higher in the hypertensive group than in the control group. Result from genotyping indicated that rs4963 was significantly associated with essential hypertension. After stratification by gender, rs4963 was associated with essential hypertension only in males. MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension. The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation. |
| 资助信息 | This study was �nancially supported by Ningbo Natural Science Foundation (2011A610037, 2012A610237), China Postdoctoral Science Foundation (20100481399), and the K. C. Wong Magna Fund in Ningbo University. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313703400001 |
| 公开日期 | 2014-10-20 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8100]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo 315211, China 2.Department of Biochemistry, School of Medicine, Ningbo University, Ningbo 315211, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Zhang LN,Ji LD,Fei LJ,et al. Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population[J]. BioMed research international,2013,2013(X):e451094. |
| APA | Zhang LN,Ji LD,Fei LJ,Yuan F,Zhang YM,&Xu J[*].(2013).Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.BioMed research international,2013(X),e451094. |
| MLA | Zhang LN,et al."Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population".BioMed research international 2013.X(2013):e451094. |
入库方式： OAI收割
来源：昆明动物研究所
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