中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明动物研究所
  3. 昆明动物研究所
  4. 遗传资源与进化国家重点实验室
  5. 分子进化基因组学
Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population

文献类型：期刊论文

作者Ji LD1,2; Chai PF3; Zhou BB3; Tang NLS4; Xing WH5; Yuan F5; Fei LJ5; Zhang LN5; Xu J[*]2,5
刊名SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
出版日期2013
卷号45期号:4页码:310-314
关键词Polymorphism tuberculosis genome-wide association study African Chinese
通讯作者xujin1@nbu.edu.cn
合作状况其它
英文摘要Genome-wide association studies (GWAS) have identified rs4331426 and rs2057178 as being associated with tuberculosis (TB) in African populations. Both are common single nucleotide polymorphisms (SNPs) in Africans, but they are much rarer in Eurasian populations. In order to corroborate these results, we carried out a case-control study in the Chinese population; these 2 SNPs were genotyped in 600 pulmonary TB patients and 618 healthy controls. The results showed that neither of the SNPs was associated with TB, even after stratification by gender, age, and smear status. Considering the limitation of poor coverage of variations in commercial available genotyping platforms in African populations, further GWAS should be conducted in other populations such as Indian and Chinese. Moreover, future genetic studies on host susceptibility to TB need to take into account all the variables, including host, environment, pathogen, and interactions.
收录类别SCI
资助信息This work was fi nancially supported by the Ningbo Natural Science Foundation (2010A610040) and the China Postdoctoral Science Foundation (20100481399), as well as the K.C. Wong Magna Fund of Ningbo University.
语种英语
WOS记录号WOS:000316693600011
公开日期2014-10-20
源URL[http://159.226.149.42:8088/handle/152453/8104]  
专题昆明动物研究所_分子进化基因组学
昆明动物研究所_遗传资源与进化国家重点实验室
作者单位1.Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, China
2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
3.Department of Tuberculosis Control, Yingzhou Centre for Disease Control and Prevention, Ningbo
4.Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong
5.Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, China
推荐引用方式
GB/T 7714		 Ji LD,Chai PF,Zhou BB,et al. Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,2013,45(4):310-314.
APA Ji LD.,Chai PF.,Zhou BB.,Tang NLS.,Xing WH.,...&Xu J[*].(2013).Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population.SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,45(4),310-314.
MLA Ji LD,et al."Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population".SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 45.4(2013):310-314.

入库方式： OAI收割

来源：昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。