Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population
文献类型：期刊论文
| 作者 | Yang JK1; Wu WJ2; He L[*]2; Zhang YP[*]1,3 |
| 刊名 | DERMATOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 229期号:3页码:210-214 |
| 关键词 | Clinical phenotypes Severe acne Susceptibility loci |
| 通讯作者 | helikm2662@126.com ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Two novel susceptibility gene loci (1q24.2 and 11p11.2) for severe acne have been identified in a genomewide association study of a Han Chinese population. Objective: The current study investigated the relationships of these gene loci with clinical phenotypes, including onset age, atrophic scarring, hypertrophic scarring and family history. Furthermore, we investigated the correlations between these four clinical phenotypes. Methods:W We used the)(2 test to compare the allele frequency among the different clinical phenotypes. We calculated Spearman's correlation coefficient to measure the relationship between the different clinical phenotypes. Results: We identified significant associations between the 11p11.2 locus and disease family history (p < 0.05). We also determined that hypertrophic scarring was moderately correlated with atrophic scarring (r(s) = 0.315). Conclusions: This study suggests that the susceptibility gene locus 11p11.2 may contribute to the complex phenotypes of severe acne, particularly in cases of hereditary severe acne, whereas there are also correlations between the different phenotypes. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the National Natu- ral Science Foundation of China (81060123), the Yunnan Natural Science Foundation (2011FA028, 2011FB175), the R&D Infra- structure and Facility Development Program of Yunnan Province (2011-307) and a Scholarship Award for Excellent Doctoral Stu- dent granted by Yunnan province. |
| 语种 | 英语 |
| WOS记录号 | WOS:000345818500008 |
| 公开日期 | 2015-01-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8210]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University 2.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology and Venereology of Yunnan Province 3.State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming , China |
| 推荐引用方式 GB/T 7714 | Yang JK,Wu WJ,He L[*],et al. Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population[J]. DERMATOLOGY,2014,229(3):210-214. |
| APA | Yang JK,Wu WJ,He L[*],&Zhang YP[*].(2014).Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population.DERMATOLOGY,229(3),210-214. |
| MLA | Yang JK,et al."Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population".DERMATOLOGY 229.3(2014):210-214. |
入库方式： OAI收割
来源：昆明动物研究所
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