Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi
文献类型：期刊论文
| 作者 | Zhang ZN1,2; Wu QY1; Zhang GZ2; Zhu YY1; Murphy RW3; Liu Z[*]3; Zou CG[*]1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e13032 |
| 通讯作者 | zhenliu@mail.kiz.ac.cn ; fushu111@qq.com |
| 合作状况 | 其它 |
| 英文摘要 | CFEM domain commonly occurs in fungal extracellular membrane proteins. To provide insights for understanding putative functions of CFEM, we investigate the evolutionary dynamics of CFEM domains by systematic comparative genomic analyses among diverse animals, plants, and more than 100 fungal species, which are representative across the entire group of fungi. We here show that CFEM domain is unique to fungi. Experiments using tissue culture demonstrate that the CFEM-containing ESTs in some plants originate from endophytic fungi. We also find that CFEM domain does not occur in all fungi. Its single origin dates to the most recent common ancestors of Ascomycota and Basidiomycota, instead of multiple origins. Although the length and architecture of CFEM domains are relatively conserved, the domain-number varies significantly among different fungal species. In general, pathogenic fungi have a larger number of domains compared to other species. Domain-expansion across fungal genomes appears to be driven by domain duplication and gene duplication via recombination. These findings generate a clear evolutionary trajectory of CFEM domains and provide novel insights into the functional exchange of CFEM-containing proteins from cell-surface components to mediators in host-pathogen interactions. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants (31070068 and 31301013) from the National Natural Science Foundation of China. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9227]  |
| 专题 | 昆明动物研究所_进化与功能基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, China 2.Xiamen Tobacco Industrial CO., LTD, Xiamen, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhang ZN,Wu QY,Zhang GZ,et al. Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi[J]. SCIENTIFIC REPORTS,2015,5(X):e13032. |
| APA | Zhang ZN.,Wu QY.,Zhang GZ.,Zhu YY.,Murphy RW.,...&Zou CG[*].(2015).Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi.SCIENTIFIC REPORTS,5(X),e13032. |
| MLA | Zhang ZN,et al."Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi".SCIENTIFIC REPORTS 5.X(2015):e13032. |
入库方式： OAI收割
来源：昆明动物研究所
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