Reappraising the Relationship Between Mitochondrial DNA Variant m.16189T > C and Type 2 Diabetes Mellitus in East Asian Populations
文献类型：期刊论文
| 作者 | Zhong L1,2; Tang J3; Yang M3; Yao YG4; Zhang YP[*]1,2; Kong QP[*]2; Sun C1; Zhou WP1,2,5 |
| 刊名 | CURRENT MOLECULAR MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:10页码:1273-1278 |
| 关键词 | Haplogroup mitochondrial DNA type 2 diabetes mellitus m.16189T>C |
| 通讯作者 | kongqp@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study using data and samples collected in a large geographic region in China. To test this hypothesis, we first performed a linear regression analysis between the prevalence of T2DM and the allele frequency of 16189C variant in 10 East Asian populations, and further genotyped this variant in two case-control cohorts from west Han Chinese (Kunming and Xining). Linear regression analysis showed that no significant correlation was observed (r(2) = 0.211, P = 0.181), and the genotyping results indicated that the m. 16189T>C frequency difference between case and control was not significant in either populations (P = 0.38 and 0.89 for Kunming and Xining, respectively). Matrilineal backgrounds constitution (in terms of haplogroups) analysis generated a similar haplogroup distribution in both populations (P>0.1). All results failed to substantiate that m. 16189T>C may play an active role in the development of T2DM in East Asian populations. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by grants from the National Natural Science Foundation of China (31200940), Education and Science Foundation of Education Department of Yunnan Province (5Y0503C, to J.T.), Bureau of Science and Technology of Yunnan Province, and Yunnan University (2011ZD01). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9249]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子人类学 昆明动物研究所_重大疾病机理的遗传学 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Kunming Medical University, Kunming 650031, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 5.Department of Molecular and Cell Biology, School of Life Science, University of Science and Technology of China, Hefei 230026, China |
| 推荐引用方式 GB/T 7714 | Zhong L,Tang J,Yang M,et al. Reappraising the Relationship Between Mitochondrial DNA Variant m.16189T > C and Type 2 Diabetes Mellitus in East Asian Populations[J]. CURRENT MOLECULAR MEDICINE,2014,14(10):1273-1278. |
| APA | Zhong L.,Tang J.,Yang M.,Yao YG.,Zhang YP[*].,...&Zhou WP.(2014).Reappraising the Relationship Between Mitochondrial DNA Variant m.16189T > C and Type 2 Diabetes Mellitus in East Asian Populations.CURRENT MOLECULAR MEDICINE,14(10),1273-1278. |
| MLA | Zhong L,et al."Reappraising the Relationship Between Mitochondrial DNA Variant m.16189T > C and Type 2 Diabetes Mellitus in East Asian Populations".CURRENT MOLECULAR MEDICINE 14.10(2014):1273-1278. |
入库方式： OAI收割
来源：昆明动物研究所
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