Evidence of recent natural selection on the Southeast Asian deletion (-(SEA)) causing alpha-thalassemia in South China
文献类型：期刊论文
| 作者 | Qiu QW1; Wu DD2; Li ZT1; Liu YH1,2; Zhang YP2; Xu XM[*]1; Yu LH1; Yan TZ3; Zhang W4,5 |
| 刊名 | BMC EVOLUTIONARY BIOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 13期号:X页码:e63 |
| 通讯作者 | gzxuxm@pub.guangzhou.gd.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: The Southeast Asian deletion (-(SEA)) is the most commonly observed mutation among diverse alpha-thalassemia alleles in Southeast Asia and South China. It is generally argued that mutation -(SEA), like other variants causing hemoglobin disorders, is associated with protection against malaria that is endemic in these regions. However, little evidence has been provided to support this claim. Results: We first examined the genetic imprint of recent positive selection on the -(SEA) allele and flanking sequences in the human alpha-globin cluster, covering a genomic region spanning similar to 410 kb, by genotyping 28 SNPs in a Chinese population consisting of 76 -(SEA) heterozygotes and 138 normal individuals. The pattern of linkage disequilibrium (LD) and the long-range haplotype test revealed a signature of positive selection. The network of inferred haplotypes suggested a single origin of the -(SEA) allele. Conclusions: Thus, our data support the hypothesis that the -(SEA) allele has been subjected to recent balancing selection, triggered by malaria |
| 收录类别 | SCI |
| 资助信息 | This work was funded by a grant from the National Natural Science Fund of China (NSFC, NO. 30971581). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9271]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P.R. China 3.Clinical Laboratory, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou 545001Guangxi, P.R. China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 5.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Qiu QW,Wu DD,Li ZT,et al. Evidence of recent natural selection on the Southeast Asian deletion (-(SEA)) causing alpha-thalassemia in South China[J]. BMC EVOLUTIONARY BIOLOGY,2013,13(X):e63. |
| APA | Qiu QW.,Wu DD.,Li ZT.,Liu YH.,Zhang YP.,...&Zhang W.(2013).Evidence of recent natural selection on the Southeast Asian deletion (-(SEA)) causing alpha-thalassemia in South China.BMC EVOLUTIONARY BIOLOGY,13(X),e63. |
| MLA | Qiu QW,et al."Evidence of recent natural selection on the Southeast Asian deletion (-(SEA)) causing alpha-thalassemia in South China".BMC EVOLUTIONARY BIOLOGY 13.X(2013):e63. |
入库方式： OAI收割
来源：昆明动物研究所
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