Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer
文献类型：期刊论文
| 作者 | Hao XD1,3,4; Yang Y5,7; He JD1,4,10; Kong QP1,4; Tang NLS[*]4,8,9; Zhang YP[*]1,2,4; Song X6; Zhao XK6; Wang LD6 |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:1页码:226-236 |
| 关键词 | telomere erosion TP53 variations allelic loss breast tumor esophageal cancer |
| 通讯作者 | nelsontang@cuhk.edu.hk ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Genomic instability caused by telomere erosion is an important mechanism of tumorigenesis. p53 plays a key role in cellular senescence and/or apoptosis associated with telomere erosion which positions p53 as a guard against tumorigenesis. The present study was undertaken to investigate the potential interactions between p53 functional mutations, polymorphisms, allelic loss and telomere erosion in 126 breast tumor patients and 68 esophageal cancer patients. Telomere length (TL) was measured by real-time quantitative PCR. Somatic mutations, polymorphisms and allelic loss in the TP53 gene were detected by direct sequencing of both tumor and normal tissue samples. Our results showed that telomeres were significantly shorter in tumors with somatic p53 mutations compared with tumors with wild-type p53 in both breast tumors (P=0.007) and esophageal cancer (P=0.001). Telomeres of patients with minor genotype CC of rs12951053 and GG of rs1042522 were significantly shorter compared to patients with other genotypes of this single nucleotide polymorphism in esophageal cancer tissue. Furthermore, TP53 allelic loss was detected and significantly associated with somatic mutations in both types of tumor tissues. These findings suggest that somatic p53 mutations, rs12951053 genotype CC and rs1042522 genotype GG contribute to erosion of telomeres, and TP53 allelic loss may be one of the representations of chromosomal instability caused by telomere erosion combined with somatic p53 mutations. These results support that the TP53 gene has a strong interaction with TL erosion in tumorigenesis |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (NSFC) and The Bureau of Science and Technology of Yunnan Province. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9282]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子人类学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming 3.Graduate School of the Chinese Academy of Sciences, Beijing 4.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 5.Department of the Breast, First People's Hospital of Kunming, Kunming 6.Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 7.Affiliated Ganmei Hospital, Kunming Medical University, Kunming 8.Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR 9.Laboratory of Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR 10.School of Life Sciences, University of Science and Technology of China, Hefei, P.R. China |
| 推荐引用方式 GB/T 7714 | Hao XD,Yang Y,He JD,et al. Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer[J]. ONCOLOGY REPORTS,2013,29(1):226-236. |
| APA | Hao XD.,Yang Y.,He JD.,Kong QP.,Tang NLS[*].,...&Wang LD.(2013).Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer.ONCOLOGY REPORTS,29(1),226-236. |
| MLA | Hao XD,et al."Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer".ONCOLOGY REPORTS 29.1(2013):226-236. |
入库方式： OAI收割
来源：昆明动物研究所
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