Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens
文献类型：期刊论文
| 作者 | Wang MS1,2,3; Li Y1,2; Peng MS1,2; Zhong L4; Wang ZJ5; Li QY5; Tu XL1,2,3; Dong Y1,2; Zhu CL1; Wang L4 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2015 |
| 卷号 | 32期号:7页码:1880-1889 |
| 关键词 | calcium-signaling pathway chicken domestication hypoxia adaptation |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; zhangyp@ mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Much like other indigenous domesticated animals, Tibetan chickens living at high altitudes (2,200-4,100 m) show specific physiological adaptations to the extreme environmental conditions of the Tibetan Plateau, but the genetic bases of these adaptations are not well characterized. Here, we assembled a de novo genome of a Tibetan chicken and resequenced whole genomes of 32 additional chickens, including Tibetan chickens, village chickens, game fowl, and Red Junglefowl, and found that the Tibetan chickens could broadly be placed into two groups. Further analyses revealed that several candidate genes in the calcium-signaling pathway are possibly involved in adaptation to the hypoxia experienced by these chickens, as these genes appear to have experienced directional selection in the two Tibetan chicken populations, suggesting a potential genetic mechanism underlying high altitude adaptation in Tibetan chickens. The candidate selected genes identified in this study, and their variants, may be useful targets for clarifying our understanding of the domestication of chickens in Tibet, and might be useful in current breeding efforts to develop improved breeds for the highlands. |
| 收录类别 | SCI |
| 资助信息 | The authors thank Andrew Willden for help in revising the manuscript.ThisworkwassupportedbytheStrategicPriority ResearchProgramoftheChineseAcademyofSciences,Grant No. XDB13020600, the Chinese 973 program (2013CB835200, 2013CB835204), and the National Natural Science Foundation of China (91331104, 31321002). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9362]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_基因起源组 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.University of Chinese Academy of Sciences, Beijing, China 4.Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming, China 5.China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China 6.Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China 7.Xishuangbanna Animal Husbandry and Veterinary Station of Yunnan Province, Jinghong, China 8.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 9.Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada |
| 推荐引用方式 GB/T 7714 | Wang MS,Li Y,Peng MS,et al. Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(7):1880-1889. |
| APA | Wang MS.,Li Y.,Peng MS.,Zhong L.,Wang ZJ.,...&Zhang YP[*].(2015).Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens.MOLECULAR BIOLOGY AND EVOLUTION,32(7),1880-1889. |
| MLA | Wang MS,et al."Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens".MOLECULAR BIOLOGY AND EVOLUTION 32.7(2015):1880-1889. |
入库方式： OAI收割
来源：昆明动物研究所
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