The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo
文献类型：期刊论文
| 作者 | Zhao H1; Du YL1; Huang JF2; Wang DD[*]2; Zhang YP[*]1,2; Chen SM2; Qing LL1,2; Wang XY1 |
| 刊名 | INFECTION GENETICS AND EVOLUTION
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:X页码:531-538 |
| 关键词 | BSE Divergence Genetic differences PRNP Polymorphisms |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; zhangyp@ mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Prion protein, encoded by the prion protein gene (PRNP), plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (TSEs). Several polymorphisms within the PRNP are known to be associated with influencing bovine spongiform encephalopathy (BSE) susceptibility in cattle, namely two insertion/deletion (indel) polymorphisms (a 23-bp indel in the putative promoter and a 12-bp indel in intron 1), the number of octapeptide repeats (octarepeats) present in coding sequence (CDS) and amino acid polymorphisms. The domestic buffaloes, Bubalus bubalis, are a ruminant involved in various aspects of agriculture. It is of interest to ask whether the PRNP polymorphisms differ between cattle and buffalo. In this study, we analyzed the previously reported polymorphisms associated with BSE susceptibility in Chinese buffalo breeds, and compared these polymorphisms in cattle with BSE, healthy cattle and buffalo by pooling data from the literature. Our analysis revealed three significant findings in buffalo: 1) extraordinarily low deletion allele frequencies of the 23- and 12-bp indel polymorphisms; 2) significantly low allelic frequencies of six octarepeats in CDS and 3) the presence of S4R, A16V, P54S, G108S, V123M, S154N and F257L substitutions in buffalo CDSs. Sequence alignments comparing the buffalo coding sequence to other species were analyzed using the McDonald-Kreitman test to reveal five groups (Bison bonasus, Bos indicus, Bos gaurus, Boselaphus tragocamelus, Syncerus caffer caffer) with significantly divergent non-synonymous substitutions from buffalo, suggesting potential divergence of buffalo PRNP and others. To the best of our knowledge this is the first study of PRNP polymorphisms associated with BSE susceptibility in Chinese buffalo. Our findings have provided evidence that buffaloes have a unique genetic background in the PRNP gene in comparison with cattle. |
| 资助信息 | This work was supported by grants of the National Natural Science Foundation of China (Grant nos. 31060302, 31260032 and 31460038), andtheProgramforInnovativeResearchTeam (inScienceandTechnolo- gy) in the University of Yunnan Province. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9449]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_结构生物信息学 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhao H,Du YL,Huang JF,et al. The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo[J]. INFECTION GENETICS AND EVOLUTION,2015,36(X):531-538. |
| APA | Zhao H.,Du YL.,Huang JF.,Wang DD[*].,Zhang YP[*].,...&Wang XY.(2015).The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.INFECTION GENETICS AND EVOLUTION,36(X),531-538. |
| MLA | Zhao H,et al."The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo".INFECTION GENETICS AND EVOLUTION 36.X(2015):531-538. |
入库方式： OAI收割
来源：昆明动物研究所
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