Genetic adaptations of the plateau zokor in high-elevation burrows.
文献类型：期刊论文
| 作者 | Shao Y1,7; Li JX2; Ge RL3; Zhong L2; Irwin DM1,4,5; Murphy RW1,6; Zhang YP[*]1,2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e17262 |
| 通讯作者 | zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The plateau zokor (Myospalax baileyi) spends its entire life underground in sealed burrows. Confronting limited oxygen and high carbon dioxide concentrations, and complete darkness, they epitomize a successful physiological adaptation. Here, we employ transcriptome sequencing to explore the genetic underpinnings of their adaptations to this unique habitat. Compared to Rattus norvegicus, genes belonging to GO categories related to energy metabolism (e.g. mitochondrion and fatty acid beta-oxidation) underwent accelerated evolution in the plateau zokor. Furthermore, the numbers of positively selected genes were significantly enriched in the gene categories involved in ATPase activity, blood vessel development and respiratory gaseous exchange, functional categories that are relevant to adaptation to high altitudes. Among the 787 genes with evidence of parallel evolution, and thus identified as candidate genes, several GO categories (e.g. response to hypoxia, oxygen homeostasis and erythrocyte homeostasis) are significantly enriched, are two genes, EPAS1 and AJUBA, involved in the response to hypoxia, where the parallel evolved sites are at positions that are highly conserved in sequence alignments from multiple species. Thus, accelerated evolution of GO categories, positive selection and parallel evolution at the molecular level provide evidences to parse the genetic adaptations of the plateau zokor for living in high-elevation burrows. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China, and the Animal Branch of the Germplasm Bank of Wild Species of Chinese Academy of Sciences (the Large Research Infrastructure Funding). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9493]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China 3.Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining 810001, Chin 4.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, M5S 1A8, Canada 5.Banting and Best Diabetes Centre, University of Toronto, Ontario, M5S 1A8, Canada 6.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, 100 Queen’s Park, Toronto, Ont., M5S 2C6, Canada 7.Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China |
| 推荐引用方式 GB/T 7714 | Shao Y,Li JX,Ge RL,et al. Genetic adaptations of the plateau zokor in high-elevation burrows.[J]. SCIENTIFIC REPORTS,2015,5(X):e17262. |
| APA | Shao Y.,Li JX.,Ge RL.,Zhong L.,Irwin DM.,...&Zhang YP[*].(2015).Genetic adaptations of the plateau zokor in high-elevation burrows..SCIENTIFIC REPORTS,5(X),e17262. |
| MLA | Shao Y,et al."Genetic adaptations of the plateau zokor in high-elevation burrows.".SCIENTIFIC REPORTS 5.X(2015):e17262. |
入库方式： OAI收割
来源：昆明动物研究所
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