Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog.
文献类型：期刊论文
| 作者 | Shao Y1,5; Wang LJ3; Zhong L2; Hong ML3; Chen HM1; Murphy RW1,4; Wu DD[*]1; Zhang YP[*]1,2; Che J[*]1 |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e17551 |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; zhangyp@ mail.kiz.ac.cn ; chej@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The crab-eating frog, Fejervarya cancrivora, is the only frog that lives near seas. It tolerates increased environmental concentrations of sodium, chloride and potassium partly by raising ion and urea levels in its blood plasma. The molecular mechanism of the adaptation remains rarely documented. Herein, we analyze transcriptomes of the crab-eating frog and its closely related saline-intolerant species, F. limnocharis, to explore the molecular basis of adaptations to such extreme environmental conditions. Analyses reveal the potential genetic mechanism underlying the adaptation to salinity for the crab-eating frog. Genes in categories associated with ion transport appear to have evolved rapidly in F. cancrivora. Both positively selected and differentially expressed genes exhibit enrichment in the GO category regulation of renal sodium excretion. In this category, the positively selected sites of ANPEP and AVPR2 encode CD13 and V2 receptors, respectively; they fall precisely on conserved domains. More differentially expressed rapidly evolved genes occur in the kidney of F. cancrivora than in F. limnocharis. Four genes involved in the regulation of body fluid levels show signs of positive selection and increased expression. Significant up-regulation occurs in several genes of F. cancrivora associated with renin-angiotensin system and aldosterone-regulated sodium reabsorption pathways, which relate to osmotic regulation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China [grant number31321002], and the Animal Branch of the GermplasmBank of Wild Species of Chinese Academy of Sciences (the Large Research Infrastructure Funding).We thank Wei-wei Zhou for helpful discussions and comments, and Jie-Qiong Jin for sample collection and technical help in the lab. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9497]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 昆明动物研究所_两栖爬行类多样性与进化 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China 3.College of Life Sciences, Hainan Normal University, Haikou 571158, China 4.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, 100 Queen’s Park, Toronto, Ont., M5S 2C6, Canada 5.Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China |
| 推荐引用方式 GB/T 7714 | Shao Y,Wang LJ,Zhong L,et al. Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog.[J]. Scientific Reports,2015,5(X):e17551. |
| APA | Shao Y.,Wang LJ.,Zhong L.,Hong ML.,Chen HM.,...&Che J[*].(2015).Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog..Scientific Reports,5(X),e17551. |
| MLA | Shao Y,et al."Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog.".Scientific Reports 5.X(2015):e17551. |
入库方式： OAI收割
来源：昆明动物研究所
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