Population variation reveals independent selection towards small body size in Chinese Debao pony
文献类型：期刊论文
| 作者 | Kader A1; Li Y2; Dong KZ1; Irwin DM3; Zhao QJ1; He XH1; Liu JF4; Pu YB1; Gorkhali NA1; Liu XX1 |
| 刊名 | GENOME BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:1页码:42-50 |
| 关键词 | Association Genetic differentiation Selective signature TBX3 XP-EHH |
| 其他题名 | This work was supported by the Agricultural Science and Technology Innovation Program of China (ASTIP- IAS01), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020600), the National Natural Science Foundation of China (31272403) and the Domestic Animals Sharing Platform in China. |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; mayuehui@caas.cn |
| 合作状况 | 其它 |
| 英文摘要 | Body size, one of the most important quantitative traits under evolutionary scrutiny, varies considerably among species and among populations within species. Revealing the genetic basis underlying this variation is very important, particularly in humans where there is a close relationship with diseases and in domestic animals as the selective patterns are associated with improvements in production traits. The Debao pony is a horse breed with small body size that is unique to China; however, it is unknown whether the size-related candidate genes identified in Western breeds also account for the small body size of the Debao pony. Here, we compared individual horses from the Debao population with other two Chinese horse populations using SNPs identified with the Equine SNP 65 Bead Chip. The previously reported size-related candidate gene HMGA2 showed a significant signature for selection, consistent with its role observed in human populations. More interestingly, we found a candidate gene TBX3, which had not been observed in previous studies on horse body size that displayed the highest differentiation and most significant association, and thus likely is the dominating factor for the small stature of the Debao pony. Further comparison between the Debao pony and other breeds of horses from around the world demonstrated that TBX3 was selected independently in the Debao pony, suggesting that there were multiple origins of small stature in the horse. |
| 资助信息 | This work was supported by the Agricultural Science and Technology Innovation Program of China (ASTIP- IAS01), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020600), the National Natural Science Foundation of China (31272403) and the Domestic Animals Sharing Platform in China. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9505]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada 4.College of Animal Science and Technology, China Agricultural University, Beijing, China |
| 推荐引用方式 GB/T 7714 | Kader A,Li Y,Dong KZ,et al. Population variation reveals independent selection towards small body size in Chinese Debao pony[J]. GENOME BIOLOGY AND EVOLUTION,2016,8(1):42-50. |
| APA | Kader A.,Li Y.,Dong KZ.,Irwin DM.,Zhao QJ.,...&Ma YH[*].(2016).Population variation reveals independent selection towards small body size in Chinese Debao pony.GENOME BIOLOGY AND EVOLUTION,8(1),42-50. |
| MLA | Kader A,et al."Population variation reveals independent selection towards small body size in Chinese Debao pony".GENOME BIOLOGY AND EVOLUTION 8.1(2016):42-50. |
入库方式： OAI收割
来源：昆明动物研究所
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