Hearing aid for vertebrates via multiple episodic adaptive events on prestin genes
文献类型：期刊论文
| 作者 | Liu Z1,2; Li GH1; Huang JF1; Murphy RW1,3; Shi P[*]1 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2012 |
| 卷号 | 29期号:9页码:2187-2198 |
| 关键词 | prestin adaptation selection electromotility tetrapods NLC |
| 通讯作者 | ship@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Auditory detection is essential for survival and reproduction of vertebrates, yet the genetic changes underlying the evolution and diversity of hearing are poorly documented. Recent discoveries concerning prestin, which is responsible for cochlear amplification by electromotility, provide an opportunity to redress this situation. We identify prestin genes from the genomes of 14 vertebrates, including three fishes, one amphibian, one lizard, one bird, and eight mammals. An evolutionary analysis of these sequences and 34 previously known prestin genes reveals for the first time that this hearing gene was under positive selection in the most recent common ancestor (MRCA) of tetrapods. This discovery might document the genetic basis of enhanced high sound sensibility in tetrapods. An investigation of the adaptive gain and evolution of electromotility, an important evolutionary innovation for the highest hearing ability of mammals, detects evidence for positive selections on the MRCA of mammals, therians, and placentals, respectively. It is suggested that electromotility determined by prestin might initially appear in the MRCA of mammals, and its functional improvements might occur in the MRCA of therians and placental mammals. Our patch clamp experiments further support this hypothesis, revealing the functional divergence of voltage-dependent nonlinear capacitance of prestin from platypus, opossum, and gerbil. Moreover, structure-based cdocking analyses detect positively selected amino acids in the MRCA of placental mammals that are key residues in sulfate anion transport. This study provides new insights into the adaptation and functional diversity of hearing sensitivity in vertebrates by evolutionary and functional analysis of the hearing gene prestin. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a start-up fund of ‘‘Hundreds-Talent Program’’ from Chinese Academy of Sciences and by grants from Key Project from National Natural Science Founda- tion of China (30930015) to P.S. and by a Visiting Professor- ship for Senior International Scientists and Discovery Grant A3148 from the Natural Sciences and Engineering Research Council (Canada) to R.W.M. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9585]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_结构生物信息学 昆明动物研究所_进化与功能基因组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, Canada |
| 推荐引用方式 GB/T 7714 | Liu Z,Li GH,Huang JF,et al. Hearing aid for vertebrates via multiple episodic adaptive events on prestin genes[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(9):2187-2198. |
| APA | Liu Z,Li GH,Huang JF,Murphy RW,&Shi P[*].(2012).Hearing aid for vertebrates via multiple episodic adaptive events on prestin genes.MOLECULAR BIOLOGY AND EVOLUTION,29(9),2187-2198. |
| MLA | Liu Z,et al."Hearing aid for vertebrates via multiple episodic adaptive events on prestin genes".MOLECULAR BIOLOGY AND EVOLUTION 29.9(2012):2187-2198. |
入库方式： OAI收割
来源：昆明动物研究所
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