Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population
文献类型：期刊论文
| 作者 | Pan H1,2,3; Kong QP1,2; Gao SJ5; Xu LY5; Zhang YP[*]1,2; Cheng YT1,2,3; Lian SG4; Yang J4 |
| 刊名 | EXPERIMENTAL GERONTOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 46期号:6页码:511-515 |
| 关键词 | Longevity Mitochondrial DNA C150T Association study Han Chinese population |
| 通讯作者 | zhangyp@mail.kiz.ac.cn, zhangyp1@263.net.cn |
| 合作状况 | 其它 |
| 英文摘要 | Human longevity has been associated with mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the C150T polymorphism in the non-coding region in previous studies especially in Europeans. This study investigated the potential association between the mtDNA C150T polymorphism and longevity in a Han Chinese population. Leukocyte mtDNAs from two groups of a Han Chinese population living in Dujiangyan city of Sichuan province, including 556 longevous individuals (90-108 years-old) and 403 unrelated controls, were analyzed and mtDNA haplogroups were determined by sequencing control regions and restriction fragment length polymorphisms (RFLPs) in coding regions. Our results did not show a universal association between the mitochondrial C150T polymorphism and longevity in this population. Even when mtDNA haplogroups defined by C150T and gender were taken into account, there was no significant association with longevity. In conclusion, the mtDNA C150T polymorphism could not present an accumulation in an elderly Han Chinese population. Previous association studies might have been influenced by nuclear DNA and/or environment factors. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (No. 2007CB507405), “Light in Western China” of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 30621092), and the Bureau of Science and Technology of Yunnan Province. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9597]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子人类学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 3.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 4.People’s Hospital of Dujiangyan City, Dujiangyan 611830, China 5.Dujiangyan Longevity Research Centre, Dujiangyan 611830, China |
| 推荐引用方式 GB/T 7714 | Pan H,Kong QP,Gao SJ,et al. Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population[J]. EXPERIMENTAL GERONTOLOGY,2011,46(6):511-515. |
| APA | Pan H.,Kong QP.,Gao SJ.,Xu LY.,Zhang YP[*].,...&Yang J.(2011).Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population.EXPERIMENTAL GERONTOLOGY,46(6),511-515. |
| MLA | Pan H,et al."Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population".EXPERIMENTAL GERONTOLOGY 46.6(2011):511-515. |
入库方式： OAI收割
来源：昆明动物研究所
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