Adaptive evolution of the first extra exon in the murid rodent prolactin gene family
文献类型：期刊论文
| 作者 | Li Y1,2; Huang JF1; Zhang YP[*]1,2 |
| 刊名 | BIOCHEMICAL GENETICS
 |
| 出版日期 | 2007 |
| 卷号 | 45期号:5-6页码:397-408 |
| 关键词 | adaptive evolution gene family prolactin rodent |
| 通讯作者 | zhangyp@public.km.yn.cn. |
| 合作状况 | 其它 |
| 英文摘要 | The prolactin gene family in rodents consists of multiple members that coordinate the processes of reproduction and pregnancy. Some members of this family acquired one or two additional exons between exon 2 and exon 3 of the prototypical 5-exon, 4-intron structure, but the evolutionary importance of this insertion is unclear. Here, we focus on those members and survey this question by molecular evolutionary methods. Phylogenetic analysis shows that those members cluster into two distinct groups. Further analysis shows that the two groups of genes originated before the divergence of mouse and rat but after that of rodents from other mammals. We compared the d (N)/d (S) values for each branch of the gene tree but found no evidence to support positive selection for any branch. We found strong evidence, however, that one site (11E) of the 13 sites of the first extra exon underwent positive selection by the site-specific models of the maximum-likelihood method. Combining our molecular evolutionary analysis with other known functional evidence, we believe that the insertion of the extra exon implies some functional adaptation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (30021004, 30430110). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9635]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_结构生物信息学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P. R. China. 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, P. R. China |
| 推荐引用方式 GB/T 7714 | Li Y,Huang JF,Zhang YP[*]. Adaptive evolution of the first extra exon in the murid rodent prolactin gene family[J]. BIOCHEMICAL GENETICS,2007,45(5-6):397-408. |
| APA | Li Y,Huang JF,&Zhang YP[*].(2007).Adaptive evolution of the first extra exon in the murid rodent prolactin gene family.BIOCHEMICAL GENETICS,45(5-6),397-408. |
| MLA | Li Y,et al."Adaptive evolution of the first extra exon in the murid rodent prolactin gene family".BIOCHEMICAL GENETICS 45.5-6(2007):397-408. |
入库方式： OAI收割
来源：昆明动物研究所
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