Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication
文献类型：期刊论文
| 作者 | Wang MS1,3; Zhang RW7; Liu HQ1,3; Zeng L1,3; Irwin DM1,5,6; Du JL7; Yao YG2,3; Wu DD[*]1,2; Su LY2,3; Zhang YP[*]1,3,4 |
| 刊名 | Cell Research
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:5页码:556-573 |
| 关键词 | chicken domestication unconscious selection genome evolution evolution of vision |
| 通讯作者 | wudongdong@mail.kiz.ac.cn |
| 英文摘要 | As noted by Darwin, chickens have the greatest phenotypic diversity of all birds, but an interesting evolutionary difference between domestic chickens and their wild ancestor, the Red Junglefowl, is their comparatively weaker vision. Existing theories suggest that diminished visual prowess among domestic chickens reflect changes driven by the relaxation of functional constraints on vision, but the evidence identifying the underlying genetic mechanisms responsible for this change has not been definitively characterized. Here, a genome-wide analysis of the domestic chicken and Red Junglefowl genomes showed significant enrichment for positively selected genes involved in the development of vision. There were significant differences between domestic chickens and their wild ancestors regarding the level of mRNA expression for these genes in the retina. Numerous additional genes involved in the development of vision also showed significant differences in mRNA expression between domestic chickens and their wild ancestors, particularly for genes associated with phototransduction and photoreceptor development, such as RHO (rhodopsin), GUCA1A, PDE6B and NR2E3. Finally, we characterized the potential role of the VIT gene in vision, which experienced positive selection and downregulated expression in the retina of the village chicken. Overall, our results suggest that positive selection, rather than relaxation of purifying selection, contributed to the evolution of vision in domestic chickens. The progenitors of domestic chickens harboring weaker vision may have showed a reduced fear response and vigilance, making them easier to be unconsciously selected and/or domesticated. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), the National Nat- ural Science Foundation of China (91331104), the 973 program (2013CB835200, 2013CB835204), and Bureau of Science and Technology of Yunnan Province, and the Youth Innovation Promo- tion Association, Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9659]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 3.Kunming College of Life Science, Unisversity of Chinese Academy of Sci- ences, Kunming, Yunnan 650204, China 4.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kun- ming, Yunnan 650091, China 5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; 6.Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada 7.Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
| 推荐引用方式 GB/T 7714 | Wang MS,Zhang RW,Liu HQ,et al. Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication[J]. Cell Research,2016,26(5):556-573. |
| APA | Wang MS.,Zhang RW.,Liu HQ.,Zeng L.,Irwin DM.,...&Peng MS.(2016).Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication.Cell Research,26(5),556-573. |
| MLA | Wang MS,et al."Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication".Cell Research 26.5(2016):556-573. |
入库方式： OAI收割
来源：昆明动物研究所
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