Molecular Evolution of Prolactin Gene Family in Rodents
文献类型：期刊论文
| 作者 | Li Y1,2,3; Zhang YP[*]1,2 |
| 刊名 | Acta Genetica Sinica
 |
| 出版日期 | 2006 |
| 卷号 | 33期号:7页码:590-597 |
| 关键词 | prolactin rodent independent gene duplication |
| 其他题名 | 啮齿目泌乳刺激素基因家族的分子进化研究 |
| 通讯作者 | zhangyp@public.km.yn.cn |
| 中文摘要 | 在大鼠基因组数据库中搜索得到两个泌乳刺激素基因家族的新成员。进一步分析显示该基因家族起源于啮齿目和其他哺乳动物分歧之后，而且大部分基因座位的重排在大、小鼠分歧之前已经完成。但PL-Ⅰ和PL-Ⅱ基因簇却是例外，它们在基因树上以物种特异的方式聚类。结合基因转换的检验、染色体上相对位置比较和基因重复时间估计的结果，认为啮齿目PL-Ⅰ和PL-Ⅱ基因是物种特异的，它们由一系列在大、小鼠分歧之后发生的基因重复事件形成。结果还揭示了在啮齿目泌乳刺激素基因家族进化过程中持续不断的发生了基因重复和基因分化事件。 |
| 英文摘要 | In this study, we identified two novel members of prolactin gene family in rat by blast searches against the published genomic database. A further analysis showed that gene duplications leading to PRL gene family in rodents occurred after rodents diverged from other mammals. Major reorganization of the gene loci in rodents was largely completed before the split of rat and mouse. But PL-Ⅰ and PL-Ⅱ genes are the exceptions, which have clustered in a species-specific manner in the phylogenetic tree. By combining results from gene conversion testing, relative chromosomal location comparison and estimated time for gene duplication we believe that rodent PL-Ⅰ and PL-Ⅱ genes are species-specific and are the results of serial duplications which occurred after the divergence of mouse and rat. Our analysis also reveals that continual gene duplication and divergence occurred during the evolution of rodent PRL gene family. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by National Natural Science Foundation of China （No.30021004, 30430110） and the ＂Light in Western China＂ |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9754]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China 3.The Graduate School, Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Li Y,Zhang YP[*]. Molecular Evolution of Prolactin Gene Family in Rodents[J]. Acta Genetica Sinica,2006,33(7):590-597. |
| APA | Li Y,&Zhang YP[*].(2006).Molecular Evolution of Prolactin Gene Family in Rodents.Acta Genetica Sinica,33(7),590-597. |
| MLA | Li Y,et al."Molecular Evolution of Prolactin Gene Family in Rodents".Acta Genetica Sinica 33.7(2006):590-597. |
入库方式： OAI收割
来源：昆明动物研究所
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