Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs
文献类型：期刊论文
| 作者 | Lu MD1,2,3; Han XM1; Ma YF1; Irwin DM1; Gao Y1; Deng JK1; Adeola AC1,2; Xie HB[*]1; Zhang YP[*]1,4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e27534 |
| 关键词 | Nomascus hainanus Critically Endangered bottleneck conservation genetics ghost alleles |
| 通讯作者 | xiehb@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn |
| 英文摘要 | A common phenotypic difference among domestic animals is variation in coat color. Six-white-point is a pigmentation pattern observed in varying pig breeds, which seems to have evolved through several different mechanistic pathways. Herein, we re-sequenced whole genomes of 31 Diannan small-ear pigs from China and found that the six-white-point coat color in Diannan small-ear pigs is likely regulated by polygenic loci, rather than by the MC1R locus. Strong associations were observed at three loci (EDNRB, CNTLN, and PINK1), which explain about 20 percent of the total coat color variance in the Diannan small-ear pigs. We found a mutation that is highly differentiated between six-white-point and black Diannan small-ear pigs, which is located in a conserved noncoding sequence upstream of the EDNRB gene and is a putative binding site of the CEBPB protein. This study advances our understanding of coat color evolution in Diannan small-ear pigs and expands our traditional knowledge of coat color being a monogenic trait. |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (31472000), the National 973 Program of China (2013CB835203), and the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (the Large Research Infrastructure Funding). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10030]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.University of Chinese Academy of Sciences, Beijing, China 4.Laboratory for Conservation and Utilization of Bio-Resources, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Lu MD,Han XM,Ma YF,et al. Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs[J]. SCIENTIFIC REPORTS,2016,6(X):e27534. |
| APA | Lu MD.,Han XM.,Ma YF.,Irwin DM.,Gao Y.,...&Zhang YP[*].(2016).Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs.SCIENTIFIC REPORTS,6(X),e27534. |
| MLA | Lu MD,et al."Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs".SCIENTIFIC REPORTS 6.X(2016):e27534. |
入库方式： OAI收割
来源：昆明动物研究所
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