Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation
文献类型：期刊论文
| 作者 | Yu L[*]1; Wang GD2; Ruan J3,4; Chen YB5; Yang CP5; Cao X2,6; Wu H1,2,7,8; Irwin DM16; Ryder OA17; Li Y18 |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 48期号:8页码:947-952 |
| 通讯作者 | yuli@ynu.edu.cn ; cw16@uchicago.edu ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro. Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys. |
| 资助信息 | This study was supported jointly and equally by the Strategic Priority Research Program of the Chinese Academy of Sciences (to Y.-P.Z., G.-D.W., and Y.-B.C.; XDB13000000) and the National Nature Science Foundation of China (to L.Y.; 91131904). L.Y. was supported by the National Program for Support of Top-Notch Young Professionals, State Key Laboratory of Genetic Resources and Evolution (GREKF14-04) and by the program Innovative Research Team in University of Yunnan Province (IRTSTYN). Y.-B.C. was supported by the National Natural Science Foundation of China (81322030, U1502224), Yunnan Province High-Level Talents Introduced Program 2013HA021, and Yunnan Applied Basic Research Projects (2014FA038). This work was supported by the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (Large Research Infrastructure Funding). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10290]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_肿瘤信号转导 |
| 作者单位 | 1.State Key Laboratory for Conservation and Utilization of Bio-resource in Yunnan, Yunnan University, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Chin 3.Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China 4.Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Chin 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China 6.Deparment of Laboratory Animal Science, Kunming Medical University, Kunming, China 7.Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, China 8.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 9.College of Life Sciences, Northwest University, Xi’an, China 10.Institute of Zoology, Shaanxi Academy of Sciences, Xi’an, China. |
| 推荐引用方式 GB/T 7714 | Yu L[*],Wang GD,Ruan J,et al. Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation[J]. NATURE GENETICS,2016,48(8):947-952. |
| APA | Yu L[*].,Wang GD.,Ruan J.,Chen YB.,Yang CP.,...&Zhang YP[*].(2016).Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation.NATURE GENETICS,48(8),947-952. |
| MLA | Yu L[*],et al."Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation".NATURE GENETICS 48.8(2016):947-952. |
入库方式： OAI收割
来源：昆明动物研究所
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