Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome
文献类型：期刊论文
| 作者 | Wu H1,2,3,4; Liu YH1,4; Liu F2,3; Wu SF2; Wang L[*]1,4; Yu L[*]1,4; Zhang YP[*]1,2; Wang GD2; Yang CT1,4; Otecko NO2,3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e35004 |
| 通讯作者 | wanglu@ynu.edu.cn ; yuli@ynu.edu.cn ; zhangyp@mail. kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to the allosome. In this study, we performed an intensive scan of the X chromosome of public genomic data generated from Tibetan Mastiff (TM) and five other dog populations for indications of high-altitude adaptation. We identified five genes showing signatures of selection on the X chromosome. Notable among these genes was angiomotin (AMOT), which is related to the process of angiogenesis. We sampled additional 11 dog populations (175 individuals in total) at continuous altitudes in China from 300 to 4,000 meters to validate and test the association between the haplotype frequency of AMOT gene and altitude adaptation. The results suggest that AMOT gene may be a notable candidate gene for the adaptation of TM to high-altitude hypoxic conditions. Our study shows that X chromosome deserves consideration in future studies of adaptive evolution. |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Nos 91531303 and 31321002), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (No. XDB13000000), the Key Research Program of the Chinese Academy of Sciences, the Youth Innovation Promotion Association, Chinese Academy of Sciences (to G.-D.W.), the CAS-TWAS President’s Fellowship Program for Doctoral Candidates to N.O.O., the grants from the National Youth Talent Support Program to L.Y., and Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10534]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 4.Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, China. |
| 推荐引用方式 GB/T 7714 | Wu H,Liu YH,Liu F,et al. Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome[J]. SCIENTIFIC REPORTS,2016,6(X):e35004. |
| APA | Wu H.,Liu YH.,Liu F.,Wu SF.,Wang L[*].,...&Otecko NO.(2016).Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome.SCIENTIFIC REPORTS,6(X),e35004. |
| MLA | Wu H,et al."Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome".SCIENTIFIC REPORTS 6.X(2016):e35004. |
入库方式： OAI收割
来源：昆明动物研究所
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