Comparative population genomics reveals genetic basis underlying body size of domestic chickens
文献类型：期刊论文
| 作者 | Wang MS1,4; Huo YX1,3; Xu HB1,4; Wu SF1,4; Peng MS1,4; Liu HQ1,4; Zeng L1,4; Irwin DM1,6,7; Li Y5; Yao YG2,4 |
| 刊名 | Journal of Molecular Cell Biology
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:6页码:542-552 |
| 关键词 | Artificial selection Body size Comparative population genomics Domestication |
| 通讯作者 | wudongdong@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Body size is the most important economic trait for animal production and breeding. Several hundreds of loci have been reported to be associated with growth trait and body weight in chickens. The loci are mapped to large genomic regions due to the low density and limited number of genetic markers in previous studies. Herein, we employed comparative population genomics to identify genetic basis underlying the small body size of Yuanbao chicken (a famous ornamental chicken) based on 89 whole genomes. The most significant signal was mapped to the BMP10 gene, whose expression was upregulated in the Yuanbao chicken. Overexpression of BMP10 induced a significant decrease in body length by inhibiting angiogenic vessel development in zebrafish. In addition, three other loci on chromosomes 1, 2, and 24 were also identified to be potentially involved in the development of body size. Our results provide a paradigm shift in identification of novel loci controlling body size variation, availing a fast and efficient strategy. These loci, particularly BMP10, add insights into ongoing research of the evolution of body size under artificial selection and have important implications for future chicken breeding. |
| 资助信息 | This study was supported by grants from the National Natural Science Foundation of China (91331104), the 973 Program (2013CB835200, 2013CB835204), Bureau of % inhibition = ISV amount of experiment group ISV amount of wild type control 1 - × 100 (a) at Beijing General Research Institute of Mining&Metallurgy on October 17, 2016 http://jmcb.oxfordjournals.org/ Downloaded from 21 Science and Technology of Yunnan Province (2015FA026), and the Youth Innovation Promotion Association, Chinese Academy of Sciences. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10580]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_进化与发育转录组学 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 3.College of Life Science, Anhui University, Hefei 230601, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China 5.Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming 650091, China 6.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada 7.Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario M5G 2C4, Canada |
| 推荐引用方式 GB/T 7714 | Wang MS,Huo YX,Xu HB,et al. Comparative population genomics reveals genetic basis underlying body size of domestic chickens[J]. Journal of Molecular Cell Biology,2016,8(6):542-552. |
| APA | Wang MS.,Huo YX.,Xu HB.,Wu SF.,Peng MS.,...&Su LY.(2016).Comparative population genomics reveals genetic basis underlying body size of domestic chickens.Journal of Molecular Cell Biology,8(6),542-552. |
| MLA | Wang MS,et al."Comparative population genomics reveals genetic basis underlying body size of domestic chickens".Journal of Molecular Cell Biology 8.6(2016):542-552. |
入库方式： OAI收割
来源：昆明动物研究所
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