Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals
文献类型：期刊论文
| 作者 | Grus WE1; Shi P1,2; Zhang YP2,3; Zhang JZ[*]1 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2005 |
| 卷号 | 102期号:16页码:5767-5772 |
| 关键词 | evolution dog cow opossum rodents |
| 通讯作者 | jianzhi@umich.edu |
| 合作状况 | 其它 |
| 英文摘要 | Pheromones are chemicals emitted and sensed by conspecifics to elicit social and sexual responses and are perceived in terrestrial vertebrates primarily by the vomeronasal organ (VNO). Pheromone receptors in the mammalian VNO are encoded by the V1R and V2R gene superfamilies. The V1R superfamily contains 187 and 102 putatively functional genes in the mouse and rat, respectively. To investigate whether this large repertoire size is typical among mammals with functional VNOs, we here describe the V1R repertoires of dog, cow, and opossum based on their draft genome sequences. The dog and cow have only 8 and 32 intact V1R genes, respectively. Thus, the intact V1R repertoire size varies by at least 23-fold among placental mammals with functional VNOs. To our knowledge, this size ratio represents the greatest among-species variation in gene family size of all mammalian gene families. Phylogenetic analysis of placental V1R genes suggests multiple losses of ancestral genes in carnivores and artiodactyls and gains of many new genes by gene duplication in rodents, manifesting massive gene births and deaths. We also identify 49 intact opossum V1R genes and discover independent expansions of the repertoire in placentals and marsupials. We further show a concordance between the V1R repertoire size and the complexity of VNO morphology, suggesting that the latter could indicate the sophistication of pheromone communications within species. In sum, our results demonstrate tremendous diversity and rapid evolution of mammalian V1R gene inventories and caution the generalization of VNO biology from rodents to all mammals. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by National Institutes of Health Grant GM67030 (to J.Z.) and by grants from the National Natural Science Foundation of China (30021004, 30430110), the Natural Science Foundation of Yun- nan, and the Chinese Academy of Sciences to Y.-p.Z. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10606]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_进化与功能基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109 2.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China |
| 推荐引用方式 GB/T 7714 | Grus WE,Shi P,Zhang YP,et al. Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(16):5767-5772. |
| APA | Grus WE,Shi P,Zhang YP,&Zhang JZ[*].(2005).Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(16),5767-5772. |
| MLA | Grus WE,et al."Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.16(2005):5767-5772. |
入库方式： OAI收割
来源：昆明动物研究所
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