Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs
文献类型：期刊论文
| 作者 | Zhou ZY1,2; Li AM3; Xie HB[*]2; Zhang YP[*]1,2,5; Adeola AC2,4; Liu YH5; Irwin DM2,6,7 |
| 刊名 | Genome biology and evolution
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:6页码:1387-1392 |
| 关键词 | pig lincRNA domestication |
| 通讯作者 | zhangyp@mail.kiz.ac.cn |
| 英文摘要 | Thousands of long intergenic noncoding RNAs (lincRNAs) have been identified in the human and mouse genomes, some of which play important roles in fundamental biological processes. The pig is an important domesticated animal, however, pig lincRNAs remain poorly characterized and it is unknown if they were involved in the domestication of the pig. Here, we used available RNA-seq resources derived from 93 samples and expressed sequence tag data sets, and identified 6,621 lincRNA transcripts from 4,515 gene loci. Among the identified lincRNAs, some lincRNA genes exhibit synteny and sequence conservation, including linc-sscg2561, whose gene neighbor Dnmt3a is associated with emotional behaviors. Both linc-sscg2561 and Dnmt3a show differential expression in the frontal cortex between domesticated pigs and wild boars, suggesting a possible role in pig domestication. This study provides the first comprehensive genome-wide analysis of pig lincRNAs. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National 863 Program of China (2011AA100304-5), the Ministry of Agriculture of China (2011ZX08009-003-006), the National 973 Program of China (2013CB835203), the National Natural Science Foundation of China (31061160189), and the Yunnan Provincial Science and Technology Department (2011AB008). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10740]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.School of Computer Science and Engineering, Xi’an University of Technology, Xi’an, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 5.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 6.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada 7.Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada |
| 推荐引用方式 GB/T 7714 | Zhou ZY,Li AM,Xie HB[*],et al. Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs[J]. Genome biology and evolution,2014,6(6):1387-1392. |
| APA | Zhou ZY.,Li AM.,Xie HB[*].,Zhang YP[*].,Adeola AC.,...&Irwin DM.(2014).Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs.Genome biology and evolution,6(6),1387-1392. |
| MLA | Zhou ZY,et al."Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs".Genome biology and evolution 6.6(2014):1387-1392. |
入库方式： OAI收割
来源：昆明动物研究所
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