Episodic evolution of prolactin gene in primates
文献类型：期刊论文
| 作者 | Li Y1,2,3; Duan ZY1; Jia L1; Zhang YP[*]1,2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2005 |
| 卷号 | 50期号:13页码:1348-1351 |
| 关键词 | prolactin primate evolution |
| 通讯作者 | zhangyp@public.km.yn.cn |
| 英文摘要 | In the present study, we obtained exon 2-5 of prolactin (PRL) gene from four primate species by PCR and sequencing. Adding other genes available in GenBank, we calculate amino acid substitution rates for prolactin gene in primate. Comparison of nonsynonymous substitution rate to synonymous substitution rate ratios shows no evidence of positive selection for any lineage of primate prolactin gene. According to this and the facts that (i) no sites under positive selection are inferred by using maximum-likelihood method; (ii) among 32 amino acid replacement that occurred along the rapid evolutionary phase, only two are included in the 40 functionally important residues, indicating that amino acid replacement tends to occur in those functionally unimportant residues; (iii) partial of prolactin function is replaced by placental lactogen in primate at the rapid evolutionary phase of prolactin gene, we thus deem that it is relaxation of purifying selection to some extent rather than positive selection that enforces the rapid evolution of primate prolactin gene. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 30021004 & 30430110), Yun- nan Bureau of Science and Technology, and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10741]  |
| 专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_细胞与分子进化开放实验室 |
| 作者单位 | 1.Laboratory of Cellular and Molecular Evolution, and Molecular Biol- ogy of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China 3.The Graduate School, Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Li Y,Duan ZY,Jia L,et al. Episodic evolution of prolactin gene in primates[J]. CHINESE SCIENCE BULLETIN,2005,50(13):1348-1351. |
| APA | Li Y,Duan ZY,Jia L,&Zhang YP[*].(2005).Episodic evolution of prolactin gene in primates.CHINESE SCIENCE BULLETIN,50(13),1348-1351. |
| MLA | Li Y,et al."Episodic evolution of prolactin gene in primates".CHINESE SCIENCE BULLETIN 50.13(2005):1348-1351. |
入库方式： OAI收割
来源：昆明动物研究所
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