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The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice

文献类型:期刊论文

作者Han MJ1,2,3; Wang HL3; Zhang HT1; Han ZZ[*]3,4,5
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2012
卷号422期号:1页码:139-145
关键词Tax-interacting protein 1 Breast cancer Beta-catenin Cell adhesion Migration Pulmonary metastasis
通讯作者zhaozhong.han@vanderbilt.edu
合作状况其它
英文摘要Tax-interacting protein 1 (TIP-1, also known as Tax1bp3) inhibited proliferation of colon cancer cells through antagonizing the transcriptional activity of beta-catenin. However, in this study, elevated TIP-1 expression levels were detected in human invasive breast cancers. Studies with two human invasive breast cancer cell lines indicated that RNAi-mediated TIP-1 knockdown suppressed the cell adhesion, proliferation, migration and invasion in vitro, and inhibited tumor growth in mammary fat pads and pulmonary metastasis in athymic mice. Biochemical studies showed that TIP-I knockdown had moderate and differential effects on the beta-catenin-regulated gene expression. but remarkably down regulated the genes for cell adhesion and motility in breast cancer cells. The decreased expression of integrins and paxillin was accompanied with reduced cell adhesion and focal adhesion formation on fibronectin-coated surface. In conclusion, this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers. (C) 2012 Elsevier Inc. All rights reserved.
资助信息This study was supported in part by NIH Grants R01CA127482 (Z. Han), P50CA128323 (J. Gore) and the Vanderbilt CTSA Grant RR024975-01 from NCRR/NIH
语种英语
WOS记录号WOS:000305046200025
公开日期2012-09-13
源URL[http://159.226.149.42:8088/handle/152453/7079]  
专题昆明动物研究所_分子免疫生物学
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China
2.Graduate School, Chinese Academy of Sciences, Beijing, China
3.Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
4.Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
5.Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
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GB/T 7714
Han MJ,Wang HL,Zhang HT,et al. The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,422(1):139-145.
APA Han MJ,Wang HL,Zhang HT,&Han ZZ[*].(2012).The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,422(1),139-145.
MLA Han MJ,et al."The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 422.1(2012):139-145.

入库方式: OAI收割

来源:昆明动物研究所

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