The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice
文献类型：期刊论文
| 作者 | Han MJ1,2,3; Wang HL3; Zhang HT1; Han ZZ[*]3,4,5 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2012 |
| 卷号 | 422期号:1页码:139-145 |
| 关键词 | Tax-interacting protein 1 Breast cancer Beta-catenin Cell adhesion Migration Pulmonary metastasis |
| 通讯作者 | zhaozhong.han@vanderbilt.edu |
| 合作状况 | 其它 |
| 英文摘要 | Tax-interacting protein 1 (TIP-1, also known as Tax1bp3) inhibited proliferation of colon cancer cells through antagonizing the transcriptional activity of beta-catenin. However, in this study, elevated TIP-1 expression levels were detected in human invasive breast cancers. Studies with two human invasive breast cancer cell lines indicated that RNAi-mediated TIP-1 knockdown suppressed the cell adhesion, proliferation, migration and invasion in vitro, and inhibited tumor growth in mammary fat pads and pulmonary metastasis in athymic mice. Biochemical studies showed that TIP-I knockdown had moderate and differential effects on the beta-catenin-regulated gene expression. but remarkably down regulated the genes for cell adhesion and motility in breast cancer cells. The decreased expression of integrins and paxillin was accompanied with reduced cell adhesion and focal adhesion formation on fibronectin-coated surface. In conclusion, this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers. (C) 2012 Elsevier Inc. All rights reserved. |
| 资助信息 | This study was supported in part by NIH Grants R01CA127482 (Z. Han), P50CA128323 (J. Gore) and the Vanderbilt CTSA Grant RR024975-01 from NCRR/NIH |
| 语种 | 英语 |
| WOS记录号 | WOS:000305046200025 |
| 公开日期 | 2012-09-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7079]  |
| 专题 | 昆明动物研究所_分子免疫生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China 2.Graduate School, Chinese Academy of Sciences, Beijing, China 3.Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA 4.Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA 5.Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA |
| 推荐引用方式 GB/T 7714 | Han MJ,Wang HL,Zhang HT,et al. The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,422(1):139-145. |
| APA | Han MJ,Wang HL,Zhang HT,&Han ZZ[*].(2012).The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,422(1),139-145. |
| MLA | Han MJ,et al."The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 422.1(2012):139-145. |
入库方式： OAI收割
来源：昆明动物研究所
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