Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice
文献类型：期刊论文
| 作者 | Han MJ1,2,3; Wang HL1; Zhang HT2; Han ZZ[*]1,4,5 |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 328期号:1页码:55-64 |
| 关键词 | TIP-1 PDZ Glioblastoma Angiogenesis Fibronectin uPA |
| 通讯作者 | zhaozhong.han@vanderbilt.edu |
| 合作状况 | 其它 |
| 英文摘要 | Glioblastoma is the most common and fatal type of primary brain tumors featured with hyperplastic blood vessels. Here, we performed meta-analyses of published data and established a correlation between high TIP-1 expression levels and the poor prognosis of glioblastoma patients. Next, we explored the biological relevance of TIP-1 expression in the pathogenesis of glioblastoma. By using orthotopic and heterotopic mouse models of human glioblastomas, this study has characterized TIP-1 as one contributing factor to the tumor-driven angiogenesis. In vitro and in vivo functional assays, along with biochemical analyses with microarrays and antibody arrays, have demonstrated that TIP-1 utilizes multiple pathways including modulating fibronectin gene expression and uPA protein secretion, to establish or maintain a pro-angiogenic microenvironment within human glioblastoma. In conclusion, this work supports one hypothesis that TIP-1 represents a novel prognostic biomarker and a therapeutic target of human glioblastoma. |
| 收录类别 | SCI |
| 资助信息 | This study was supported in part by NIH Grants R01CA127482 (Z. Han) and P50 CA128323 (J. Gore). |
| 语种 | 英语 |
| WOS记录号 | WOS:000311661700007 |
| 公开日期 | 2014-10-20 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8102]  |
| 专题 | 昆明动物研究所_分子免疫生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA 2.Key Laboratory of Animal Models & Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Yunnan, China 3.Graduate School, Chinese Academy of Sciences, Beijing, China 4.Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA 5.Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA |
| 推荐引用方式 GB/T 7714 | Han MJ,Wang HL,Zhang HT,et al. Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice[J]. CANCER LETTERS,2013,328(1):55-64. |
| APA | Han MJ,Wang HL,Zhang HT,&Han ZZ[*].(2013).Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice.CANCER LETTERS,328(1),55-64. |
| MLA | Han MJ,et al."Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice".CANCER LETTERS 328.1(2013):55-64. |
入库方式： OAI收割
来源：昆明动物研究所
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