High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96
文献类型：期刊论文
| 作者 | Zhou YK1; Liang Z2; Guo Y3; Zhang HT[*]4; Wang KH[*]5 |
| 刊名 | MOLECULAR AND CELLULAR ENDOCRINOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 404期号:X页码:75-81 |
| 关键词 | CYP24A1 1,25(OH)(2)D-3 High glucose |
| 通讯作者 | zht79571@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Vitamin D deficiency or insufficiency is an independent risk factor for diabetic peripheral neuropathy (DPN), but the relationship between 1,25(OH)(2)D-3 and DPN remains unknown. We found that 1,25(OH)(2)D-3 stimulated the secretion of nerve growth factor (NGF) in rat Schwann cell line RSC96, but ability of 1,25(OH)(2)D-3 to increase NGF protein was impaired under high glucose conditions. High glucose upregulated the expression of CYP24A1 protein, which catalyzes the conversion of 1,25(OH)(2)D-3 into inactive products, further impairing the ability of 1,25(OH)(2)D-3 to upregulate NGF secretion in Schwann cells. Inhibition of CYP24A1 protein expression ameliorated the secretion of NGF in response to 1,25(OH)(2)D-3. The findings of this study suggest that CYP24A1 protein plays an important role in the relationship between DPN and 1,25(OH)(2)D-3. |
| 收录类别 | SCI |
| 资助信息 | This work was funded by the Applied Basic Research Plans Program of Yunnan Province (2013FB204) and Gastrointestinal Surgery Innovation Team Project of Yunnan province (2012HC013), Health System Leading Talent Project of Yunnan province (L-201205). |
| 语种 | 英语 |
| WOS记录号 | WOS:000351645700009 |
| 公开日期 | 2015-04-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8307]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_比较基因组学 |
| 作者单位 | 1.Department of Endocrinology and Metabolism, First People’s Hospital of Yunnan Province (The Kunhua Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan, China 2.Department of Information Center, First People’s Hospital of Yunnan Province (The Kunhua Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan, China 3.The State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Chongqing Center for Biomedical Research and Equipment Development, Chongqing Academy of Science and Technology, Chongqing, China 5.Department of General Surgery, First People’s Hospital of Yunnan Province (The Kunhua Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhou YK,Liang Z,Guo Y,et al. High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2015,404(X):75-81. |
| APA | Zhou YK,Liang Z,Guo Y,Zhang HT[*],&Wang KH[*].(2015).High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96.MOLECULAR AND CELLULAR ENDOCRINOLOGY,404(X),75-81. |
| MLA | Zhou YK,et al."High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96".MOLECULAR AND CELLULAR ENDOCRINOLOGY 404.X(2015):75-81. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。