Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon
文献类型：期刊论文
| 作者 | Zheng YT1; Chan WL2; Chan P3; Huang H2; Tam SC[*]2 |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2001 |
| 卷号 | 496期号:2-3页码:139-142 |
| 关键词 | trichosanthin ribosome-inactivating protein anti-viral acyclovir interferon herpes simplex virus |
| ISSN号 | 0014-5793 |
| 通讯作者 | mtam@cuhk.edu.hk |
| 合作状况 | 其它 |
| 中文摘要 | Trichosanthin (TCS) is a type I ribosome-inactivating protein that has a wide range of pharmacological activities. The present study investigated the effectiveness of TCS on herpes simplex virus (HSV-1). The anti-viral activity and toxicity of TCS on Vero cells were measured. Results showed that the ED50, TD50 and the therapeutic indices were 38.5, 416.5 and 10.9 mug/ mi, respectively. Anti-viral activity of TCS was substantially potentiated when it was used in conjunction with other anti-viral agents. The ED50 of TCS was reduced 125-fold by acyclovir at a concentration of 0.001 mug/ml, which was practically devoid of significant anti-viral activity. Similarly, the ED50 of TCS was reduced 100-fold by interferon-alpha 2a at a concentration of 100 IU/ ml. In conclusion, TCS is effective against HSV-1 and other antiviral agents such as acyclovir or interferon can potentiate its action substantially. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by The Chinese University of Hong Kong Direct Grant 2040855. |
| 原文出处 | 2001496139.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4519]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China 3.Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China |
| 推荐引用方式 GB/T 7714 | Zheng YT,Chan WL,Chan P,et al. Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon[J]. FEBS LETTERS,2001,496(2-3):139-142. |
| APA | Zheng YT,Chan WL,Chan P,Huang H,&Tam SC[*].(2001).Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon.FEBS LETTERS,496(2-3),139-142. |
| MLA | Zheng YT,et al."Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon".FEBS LETTERS 496.2-3(2001):139-142. |
入库方式： OAI收割
来源：昆明动物研究所
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