Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
文献类型：期刊论文
| 作者 | Wang Q1,3; Ding ZH2; Liu JK2; Zheng YT[*]1 |
| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 64期号:3页码:189-194 |
| 关键词 | Xanthohumol Anti-HIV-1 Reverse transcriptase HIV entry |
| ISSN号 | 0166-3542 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC 50 values were 0.82, 1.28 and 0.50?g/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC 50 value of 20.74?g/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by grants to Dr. Zheng from the Natural Science Foundation of China (30471605); the Natural Science Foun- dation of Yunnan Province (2002C0066M, 2003C0022R); CASKnowledgeInnovationProjects(KSCX2-SW-216),and National 863 Program (2003AA219142). |
| 原文出处 | 200464189.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4529]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China 3.The Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Wang Q,Ding ZH,Liu JK,et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus[J]. ANTIVIRAL RESEARCH,2004,64(3):189-194. |
| APA | Wang Q,Ding ZH,Liu JK,&Zheng YT[*].(2004).Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.ANTIVIRAL RESEARCH,64(3),189-194. |
| MLA | Wang Q,et al."Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus".ANTIVIRAL RESEARCH 64.3(2004):189-194. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。