Zinc coupling potentiates anti-HIV-1 activity of baicalin
文献类型：期刊论文
| 作者 | Wang Q1,3; Wang YT2; Pu SP2; Zheng YT[*]1 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004 |
| 卷号 | 324期号:2页码:605-610 |
| 关键词 | Baicalin HIV-1 RT HIV entry Anti-HIV activity |
| ISSN号 | 0006-291X |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher anti-HIV-1 activity compared with those of BA in vitro. The CC50s of BA-Zn and BA were 221.52 and 101.73 microM, respectively. The cytotoxicity of BA-Zn was about 1.2-fold lower than that of BA. The BA and BA-Zn inhibited HIV-1 induced syncytium formation, HIV-1 p24 antigen and HIV-1 RT production. The EC50s of BA-Zn on inhibiting HIV-1 induced syncytium formation (29.08 microM) and RT production (31.17 microM) were lower than those of BA (43.27 and 47.34 microM, respectively). BA-Zn was more effective than BA in inhibiting the activities of recombinant RT and HIV-1 entry into host cells. Zinc coupling enhanced the anti-HIV-1 activity of baicalin. |
| 收录类别 | SCI |
| 资助信息 | The work was supported by grants to Dr. Zheng from the Natural Science Foun- dation of China (39970851); the Natural Science Foun- dation of Yunnan (2002C0066M; 2003C0022R); CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142). |
| 原文出处 | 2004324605.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4531]  |
| 专题 | 昆明动物研究所_分子免疫药理学 |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 2.Kunming Institute of Precious Metals, Kunming 650221, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China |
| 推荐引用方式 GB/T 7714 | Wang Q,Wang YT,Pu SP,et al. Zinc coupling potentiates anti-HIV-1 activity of baicalin[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,324(2):605-610. |
| APA | Wang Q,Wang YT,Pu SP,&Zheng YT[*].(2004).Zinc coupling potentiates anti-HIV-1 activity of baicalin.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,324(2),605-610. |
| MLA | Wang Q,et al."Zinc coupling potentiates anti-HIV-1 activity of baicalin".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324.2(2004):605-610. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。