Synthesis and anti-HIV-1 activity of S-dihydro(alkyloxy)benzyloxypyrimidine derivatives
文献类型：期刊论文
| 作者 | Rao ZK1; Long J2; Zhang SS1; He M1; Ou LC1; Zheng YT[*]2; He YP[*]1; Li C1 |
| 刊名 | MONATSHEFTE FUR CHEMIE
 |
| 出版日期 | 2008 |
| 卷号 | 139期号:8页码:967-974 |
| 关键词 | NNRTIs S-DABOs antiviral activity HIV-1 |
| ISSN号 | 0026-9247 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn ; yphe@ynu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Several 2-heteroaryl-, 2-heteroarylcarbonylmethyl-, 2-arylcarbonylmethyl, and 2-arylethyl derivatives of S-dihydro(alkyloxy)benzyloxypyrimidines have been synthesized and the anti-HIV activities of these compounds were tested in C8166 cell and against RT enzyme. It was found that some of these compounds showed good activity against HIV-1 (EC(50) = 0.014-0.8 mu M) with low toxicity (CC(50) value of 222-564 mu M) and high selectivity (SI value of 278-37743). The structure-activity relationships (SAR) of these compounds have also been discussed. |
| 收录类别 | SCI |
| 资助信息 | This research was supported by the National Natural Science Foundation of China (Grant No. 30530179), the Natural Science Foundation of education office of Yunnan province (5Z0475C) to Dr. Y.P. He, the knowledge Innovation Program of Chinese Academy of Sciences (KSCX1-YW-R-24), 973 Program (2006CB504200), Key Scientific and Technological projects of Yunnan (2004NG12) to Dr. Y.T. Zheng. We would like to acknowledge MRC AIDS Research Project (UK) for providing cell lines and virus. |
| 原文出处 | 2008139967.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/4631]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, People’s Republic of China 2.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Rao ZK,Long J,Zhang SS,et al. Synthesis and anti-HIV-1 activity of S-dihydro(alkyloxy)benzyloxypyrimidine derivatives[J]. MONATSHEFTE FUR CHEMIE,2008,139(8):967-974. |
| APA | Rao ZK.,Long J.,Zhang SS.,He M.,Ou LC.,...&Li C.(2008).Synthesis and anti-HIV-1 activity of S-dihydro(alkyloxy)benzyloxypyrimidine derivatives.MONATSHEFTE FUR CHEMIE,139(8),967-974. |
| MLA | Rao ZK,et al."Synthesis and anti-HIV-1 activity of S-dihydro(alkyloxy)benzyloxypyrimidine derivatives".MONATSHEFTE FUR CHEMIE 139.8(2008):967-974. |
入库方式： OAI收割
来源：昆明动物研究所
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